Ximena León-Lara, Uriel Pérez-Blanco, Marco A Yamazaki-Nakashimada, Juan Carlos Bustamante-Ogando, Nancy Aguilar-Gómez, Hernán Cristerna-Tarrasa, Aidé-Tamara Staines-Boone, Omar J Saucedo-Ramírez, Eunice Fregoso-Zuñiga, Ana-Paola Macías-Robles, María R Canseco-Raymundo, Marco Venancio-Hernández, Cristina Moctezuma-Trejo, Berenise Gámez-González, Carmen Zarate-Hernández, Roselia Ramírez-Rivera, Selma Scheffler-Mendoza, Nancy Jiménez-Polvo, Leticia Hernández-Nieto, Jocelyn Carmona-Vargas, María L García-Cruz, Óscar Zavaleta-Martínez, Carla M Román-Montes, Victoria Cervantes-Parra, Anelena González-Reynoso, Rogelio Guzmán-Cotaya, Francisco Espinosa-Rosales, Patricia Saltigeral-Simental, Sara Espinosa-Padilla, Lizbeth Blancas Galicia
{"title":"在一组 79 名慢性肉芽肿病患者中描述卡介苗和结核病。","authors":"Ximena León-Lara, Uriel Pérez-Blanco, Marco A Yamazaki-Nakashimada, Juan Carlos Bustamante-Ogando, Nancy Aguilar-Gómez, Hernán Cristerna-Tarrasa, Aidé-Tamara Staines-Boone, Omar J Saucedo-Ramírez, Eunice Fregoso-Zuñiga, Ana-Paola Macías-Robles, María R Canseco-Raymundo, Marco Venancio-Hernández, Cristina Moctezuma-Trejo, Berenise Gámez-González, Carmen Zarate-Hernández, Roselia Ramírez-Rivera, Selma Scheffler-Mendoza, Nancy Jiménez-Polvo, Leticia Hernández-Nieto, Jocelyn Carmona-Vargas, María L García-Cruz, Óscar Zavaleta-Martínez, Carla M Román-Montes, Victoria Cervantes-Parra, Anelena González-Reynoso, Rogelio Guzmán-Cotaya, Francisco Espinosa-Rosales, Patricia Saltigeral-Simental, Sara Espinosa-Padilla, Lizbeth Blancas Galicia","doi":"10.1007/s10875-024-01778-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Chronic granulomatous disease (CGD) is an inherited immunodeficiency caused by pathogenic variants of genes encoding the enzyme complex NADPH oxidase. In countries where tuberculosis (TB) is endemic and the Bacillus Calmette-Guérin (BCG) vaccine is routinely administered, mycobacteria are major disease-causing pathogens in CGD. However, information on the clinical evolution and treatment of mycobacterial diseases in patients with CGD is limited. The present study describes the adverse reactions to BCG and TB in Mexican patients with CGD.</p><p><strong>Methods: </strong>Patients with CGD who were evaluated at the Immunodeficiency Laboratory of the National Institute of Pediatrics between 2013 and 2024 were included. Medical records were reviewed to determine the clinical course and treatment of adverse reactions to BCG and TB disease.</p><p><strong>Results: </strong>A total of 79 patients with CGD were included in this study. Adverse reactions to BCG were reported in 55 (72%) of 76 patients who received the vaccine. Tuberculosis was diagnosed in 19 (24%) patients. Relapse was documented in three (10%) of 31 patients with BGC-osis and six (32%) of 19 patients with TB, despite antituberculosis treatment. There was no difference in the frequency of BCG and TB disease between patients with pathogenic variants of the X-linked CYBB gene versus recessive variants.</p><p><strong>Conclusions: </strong>This report highlights the importance of considering TB in endemic areas and BCG complications in children with CGD to enable appropriate diagnostic and therapeutic approaches to improve prognosis and reduce the risk of relapse.</p>","PeriodicalId":15531,"journal":{"name":"Journal of Clinical Immunology","volume":"44 8","pages":"171"},"PeriodicalIF":7.2000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Description of BCG and Tuberculosis Disease in a Cohort of 79 Patients with Chronic Granulomatous Disease.\",\"authors\":\"Ximena León-Lara, Uriel Pérez-Blanco, Marco A Yamazaki-Nakashimada, Juan Carlos Bustamante-Ogando, Nancy Aguilar-Gómez, Hernán Cristerna-Tarrasa, Aidé-Tamara Staines-Boone, Omar J Saucedo-Ramírez, Eunice Fregoso-Zuñiga, Ana-Paola Macías-Robles, María R Canseco-Raymundo, Marco Venancio-Hernández, Cristina Moctezuma-Trejo, Berenise Gámez-González, Carmen Zarate-Hernández, Roselia Ramírez-Rivera, Selma Scheffler-Mendoza, Nancy Jiménez-Polvo, Leticia Hernández-Nieto, Jocelyn Carmona-Vargas, María L García-Cruz, Óscar Zavaleta-Martínez, Carla M Román-Montes, Victoria Cervantes-Parra, Anelena González-Reynoso, Rogelio Guzmán-Cotaya, Francisco Espinosa-Rosales, Patricia Saltigeral-Simental, Sara Espinosa-Padilla, Lizbeth Blancas Galicia\",\"doi\":\"10.1007/s10875-024-01778-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Chronic granulomatous disease (CGD) is an inherited immunodeficiency caused by pathogenic variants of genes encoding the enzyme complex NADPH oxidase. In countries where tuberculosis (TB) is endemic and the Bacillus Calmette-Guérin (BCG) vaccine is routinely administered, mycobacteria are major disease-causing pathogens in CGD. However, information on the clinical evolution and treatment of mycobacterial diseases in patients with CGD is limited. The present study describes the adverse reactions to BCG and TB in Mexican patients with CGD.</p><p><strong>Methods: </strong>Patients with CGD who were evaluated at the Immunodeficiency Laboratory of the National Institute of Pediatrics between 2013 and 2024 were included. Medical records were reviewed to determine the clinical course and treatment of adverse reactions to BCG and TB disease.</p><p><strong>Results: </strong>A total of 79 patients with CGD were included in this study. Adverse reactions to BCG were reported in 55 (72%) of 76 patients who received the vaccine. Tuberculosis was diagnosed in 19 (24%) patients. Relapse was documented in three (10%) of 31 patients with BGC-osis and six (32%) of 19 patients with TB, despite antituberculosis treatment. There was no difference in the frequency of BCG and TB disease between patients with pathogenic variants of the X-linked CYBB gene versus recessive variants.</p><p><strong>Conclusions: </strong>This report highlights the importance of considering TB in endemic areas and BCG complications in children with CGD to enable appropriate diagnostic and therapeutic approaches to improve prognosis and reduce the risk of relapse.</p>\",\"PeriodicalId\":15531,\"journal\":{\"name\":\"Journal of Clinical Immunology\",\"volume\":\"44 8\",\"pages\":\"171\"},\"PeriodicalIF\":7.2000,\"publicationDate\":\"2024-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10875-024-01778-7\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10875-024-01778-7","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Description of BCG and Tuberculosis Disease in a Cohort of 79 Patients with Chronic Granulomatous Disease.
Purpose: Chronic granulomatous disease (CGD) is an inherited immunodeficiency caused by pathogenic variants of genes encoding the enzyme complex NADPH oxidase. In countries where tuberculosis (TB) is endemic and the Bacillus Calmette-Guérin (BCG) vaccine is routinely administered, mycobacteria are major disease-causing pathogens in CGD. However, information on the clinical evolution and treatment of mycobacterial diseases in patients with CGD is limited. The present study describes the adverse reactions to BCG and TB in Mexican patients with CGD.
Methods: Patients with CGD who were evaluated at the Immunodeficiency Laboratory of the National Institute of Pediatrics between 2013 and 2024 were included. Medical records were reviewed to determine the clinical course and treatment of adverse reactions to BCG and TB disease.
Results: A total of 79 patients with CGD were included in this study. Adverse reactions to BCG were reported in 55 (72%) of 76 patients who received the vaccine. Tuberculosis was diagnosed in 19 (24%) patients. Relapse was documented in three (10%) of 31 patients with BGC-osis and six (32%) of 19 patients with TB, despite antituberculosis treatment. There was no difference in the frequency of BCG and TB disease between patients with pathogenic variants of the X-linked CYBB gene versus recessive variants.
Conclusions: This report highlights the importance of considering TB in endemic areas and BCG complications in children with CGD to enable appropriate diagnostic and therapeutic approaches to improve prognosis and reduce the risk of relapse.
期刊介绍：
The Journal of Clinical Immunology publishes impactful papers in the realm of human immunology, delving into the diagnosis, pathogenesis, prognosis, or treatment of human diseases. The journal places particular emphasis on primary immunodeficiencies and related diseases, encompassing inborn errors of immunity in a broad sense, their underlying genotypes, and diverse phenotypes. These phenotypes include infection, malignancy, allergy, auto-inflammation, and autoimmunity. We welcome a broad spectrum of studies in this domain, spanning genetic discovery, clinical description, immunologic assessment, diagnostic approaches, prognosis evaluation, and treatment interventions. Case reports are considered if they are genuinely original and accompanied by a concise review of the relevant medical literature, illustrating how the novel case study advances the field. The instructions to authors provide detailed guidance on the four categories of papers accepted by the journal.
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