介孔二氧化硅纳米颗粒:治疗肺癌的多功能载体平台。

Nanomedicine (London, England) Pub Date : 2024-06-20 Epub Date: 2024-05-20 DOI:10.1080/17435889.2024.2348438
Smriti Dhingra, Shuchi Goyal, Divya Thirumal, Preety Sharma, Gurpreet Kaur, Neeraj Mittal
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引用次数: 0

摘要

介孔二氧化硅纳米粒子(MSNPs)是一种经过全面研究的无机纳米粒子,用于递送治疗药物。MSNP 为各种疾病,尤其是癌症和传染性疾病的治疗带来了革命性的变化。本文回顾了 MSNPs 用于肺癌治疗的可行性。然而,在成功转化的过程中还面临着一些挑战,如毒理学、免疫学、大规模生产和监管问题,这使得将这些发现从实验室转化到临床极为困难。本综述重点介绍了靶向给药的最新发展、特点、作用机制和定制。本综述还涵盖了最新数据,这些数据揭示了 MSNPs 在抗击肺癌方面非凡的治疗潜力以及未来的障碍。
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Mesoporous silica nanoparticles: a versatile carrier platform in lung cancer management.

Mesoporous silica nanoparticles (MSNPs) are inorganic nanoparticles that have been comprehensively investigated and are intended to deliver therapeutic agents. MSNPs have revolutionized the therapy for various conditions, especially cancer and infectious diseases. In this article, the viability of MSNPs' administration for lung cancer therapy has been reviewed. However, certain challenges lay ahead in the successful translation such as toxicology, immunology, large-scale production, and regulatory matters have made it extremely difficult to translate such discoveries from the bench to the bedside. This review highlights recent developments, characteristics, mechanism of action and customization for targeted delivery. This review also covers the most recent data that sheds light on MSNPs' extraordinary therapeutic potential in fighting lung cancer as well as future hurdles.

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