碳纤维增强聚醚醚酮(PEEK)复合材料板不同铺设结构下的骨愈合。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-08-08 DOI:10.1002/jbm.b.35463
Agnieszka Sabik
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引用次数: 0

摘要

骨折的二次愈合需要使用适当的固定器。一般来说,钢或钛装置是最常用的。然而,近年来,复合材料结构因其高强度重量比和其他优点(如放射性)而成为一种极具吸引力的替代方案。根据美国食品和药物管理局(FDA)的规定,唯一允许植入人体的单向增强复合材料是碳纤维(CF)增强聚醚醚酮(PEEK)。在这项研究中,我们在有限元法的框架内研究了采用交叉层和角层结构的 CF/PEEK 板组装的长骨的愈合过程。通过使用基于普伦德加斯特理论的机械调节模型模拟愈合过程。八面体剪切应变和间隙流体速度决定了细胞的转化。该过程每天迭代运行,假设每天只有一个载荷循环。断裂受到轴向和横向力的作用。计算中使用了 Abaqus 程序。结果表明,CF/PEEK 复合材料的角层层压方案似乎为软茧向骨组织的转化提供了更好的条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bone healing under different lay-up configuration of carbon fiber-reinforced PEEK composite plates

Secondary healing of fractured bones requires an application of an appropriate fixator. In general, steel or titanium devices are used mostly. However, in recent years, composite structures arise as an attractive alternative due to high strength to weight ratio and other advantages like, for example, radiolucency. According to Food and Drug Administration (FDA), the only unidirectionally reinforced composite allowed to be implanted in human bodies is carbon fiber (CF)-reinforced poly-ether-ether-ketone (PEEK). In this work, the healing process of long bone assembled with CF/PEEK plates with cross- and angle-ply lay-up configurations is studied in the framework of finite element method. The healing is simulated by making use of the mechanoregulation model basing on the Prendergast theory. Cells transformation is determined by the octahedral shear strain and interstitial fluid velocity. The process runs iteratively assuming single load cycle each day. The fracture is subjected to axial and transverse forces. In the computations, the Abaqus program is used. It is shown that the angle-ply lamination scheme of CF/PEEK composite seems to provide better conditions for the transformation of the soft callus into the bone tissue.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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