场效应和先驱基因驱动膀胱癌的发生

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-08-12 DOI:10.1038/s41585-024-00929-0
Maria Chiara Masone
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引用次数: 0

摘要

常见的上皮癌是由发育不良或原位癌演变而来的,这一观点因在外观正常的细胞中发现隐性疾病(称为场效应)而受到质疑,场效应涉及可能在粘膜上形成大斑块的区域。在发表于《细胞报告》(Cell Reports)上的一项新研究中,作者们开发了一种创新的全器官图谱绘制方法,该方法与基因组标记相结合,有助于剖析肿瘤前克隆最初克隆扩增的事件序列。这一策略被用于识别肿瘤抑制因子 RB1 周围区域的 FR 基因。研究发现,多态性缺失与肿瘤前克隆的早期克隆扩增有关的最小区段为 1.7 Mb,其中包括 20 个推测的候选基因。通过对 RB1 周围 5 Mb 区段的表达研究,确定了五个 FR 基因,这些基因在 50%的样本中表达下调至少两倍:ITM2B、LPAR6、MLNR、CAB39L和ARL11。高甲基化被确定为这些基因沉默的主要机制。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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