{"title":"麦角毒素 L/N 环的规模化合成","authors":"","doi":"10.1016/j.tetlet.2024.155221","DOIUrl":null,"url":null,"abstract":"<div><p>A scalable method for synthesizing the L/N ring of maitotoxin corresponding to an unnatural <span>l</span>-glucose derivative was developed via the MacMillan method and C-glycosylation under flow conditions. The longest linear sequence from <em>Z</em>-2-buten-1,4-diol was 7 steps with 10 total steps.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Scalable synthesis of the L/N ring of maitotoxin\",\"authors\":\"\",\"doi\":\"10.1016/j.tetlet.2024.155221\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A scalable method for synthesizing the L/N ring of maitotoxin corresponding to an unnatural <span>l</span>-glucose derivative was developed via the MacMillan method and C-glycosylation under flow conditions. The longest linear sequence from <em>Z</em>-2-buten-1,4-diol was 7 steps with 10 total steps.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003162\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003162","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
A scalable method for synthesizing the L/N ring of maitotoxin corresponding to an unnatural l-glucose derivative was developed via the MacMillan method and C-glycosylation under flow conditions. The longest linear sequence from Z-2-buten-1,4-diol was 7 steps with 10 total steps.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.