Melissa Emamalipour, Sara Shamdani, Behzad Mansoori, Georges Uzan, Sina Naserian
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引用次数: 0
摘要
尽管生物医学研究取得了巨大进步,但癌症仍然是全球死亡的主要原因之一。人们提出并应用了多种治疗癌症的方法,并取得了令人瞩目的成果。以免疫检查点信号通路为靶点的免疫疗法被证明是最有效的疗法之一。在这篇综述文章中,我们将重点讨论最近发现的 TNFα-TNFR2 信号通路,它控制着许多免疫调节细胞和促血管生成细胞的免疫和促血管生成特性,如内皮祖细胞(EPCs)、间充质干细胞(MSCs)和调节性 T 细胞(Tregs)。由于这些细胞的生物特性,它们在癌症进展和转移中发挥着重要作用。因此,我们将讨论抗肿瘤坏死因子受体 2(TNFR2)疗法的优缺点。它能阻断上述细胞的免疫抑制和促血管生成行为,干扰肿瘤的生长和存活。
The implications of the TNFα-TNFR2 immune checkpoint signaling pathway in cancer treatment: From immunoregulation to angiogenesis.
Despite the tremendous advances that have been made in biomedical research, cancer remains one of the leading causes of death worldwide. Several therapeutic approaches have been suggested and applied to treat cancer with impressive results. Immunotherapy based on targeting immune checkpoint signaling pathways proved to be one of the most efficient. In this review article, we will focus on the recently discovered TNFα-TNFR2 signaling pathway, which controls the immunological and pro-angiogenic properties of many immunoregulatory and pro-angiogenic cells such as endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and regulatory T cells (Tregs). Due to their biological properties, these cells can play a major role in cancer progression and metastasis. Therefore, we will discuss the advantages and disadvantages of an anti-TNFR2 treatment that could carry two faces under one hood. It interrupts the immunosuppressive and pro-angiogenic behaviors of the above-mentioned cells and interferes with tumor growth and survival.
期刊介绍:
The International Journal of Cancer (IJC) is the official journal of the Union for International Cancer Control—UICC; it appears twice a month. IJC invites submission of manuscripts under a broad scope of topics relevant to experimental and clinical cancer research and publishes original Research Articles and Short Reports under the following categories:
-Cancer Epidemiology-
Cancer Genetics and Epigenetics-
Infectious Causes of Cancer-
Innovative Tools and Methods-
Molecular Cancer Biology-
Tumor Immunology and Microenvironment-
Tumor Markers and Signatures-
Cancer Therapy and Prevention