蛋白病正电子发射断层成像的新目标

npj Imaging Pub Date : 2024-08-21 DOI:10.1038/s44303-024-00032-4

Melissa Chassé, Neil Vasdev

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摘要

神经退行性疾病的正电子发射断层扫描（PET）成像历来只关注少数几个既定靶点。针对新型生物靶点开发的选择性 PET 放射线racers 可为蛋白质病的神经病理学研究提供新的方法，并将促进我们对神经退行性病变的了解。本视角旨在重点介绍最近针对蛋白病的五个新靶点（即 mHTT、BACE1、TDP-43、OGA 和 CH24H）开发的 PET 放射性racers。

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Emerging targets for positron emission tomography imaging in proteinopathies

Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The development of selective PET radiotracers for novel biological targets enables new ways to interrogate the neuropathology of proteinopathies and will advance our understanding of neurodegeneration. This perspective aims to highlight recent PET radiotracers developed for five emerging targets in proteinopathies (i.e., mHTT, BACE1, TDP-43, OGA, and CH24H).

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npj Imaging

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