鸡体内药物残留的快速、定量和同步检测及免疫测定研究。

IF 1.4 Q4 PHARMACOLOGY & PHARMACY Reviews on recent clinical trials Pub Date : 2024-08-20 DOI:10.2174/0115748871305331240724104132
Mohamad Hesam Shahrajabian, Wenli Sun
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引用次数: 0

摘要

如果在家禽和牲畜饲养过程中考虑到适当的给药方法并控制停药期,就可以在相对安全的范围内监测不同的药物残留水平,而不会对人类健康造成危害。抗菌素是抑制微生物生长的因子,畜牧业中的抗生素残留被认为是导致动物和人类产生抗菌素耐药性的潜在原因。抗菌药耐药性与微生物在抗菌药成分的抑制作用下存活的能力有关。鸡肉中的抗生素残留物对消费者的健康有负面影响,是人类健康关注的问题。与兽药应用相关的一些被忽视的方面可能会威胁到人类和动物及其环境的安全。检测化学污染物对确保食品质量至关重要。兽药中使用的最重要的抗生素家族包括:β-内酰胺类(青霉素类和头孢菌素类)、四环素类、氯霉素类、大环内酯类、广霉素类、林可霉素类、磺胺类、硝基呋喃类、硝基咪唑类、三甲双胍类、多粘菌素类、喹诺酮类和大环内酯类(糖肽类、ansamycins 和氨基糖苷类)。抗生素残留是导致抗生素耐药性产生的主要原因,这被认为是全球人类和动物健康的主要问题。抗生素的错误应用和滥用有可能在鸡肉的可食用组织中产生残留,从而导致过敏性体质的消费者过敏和中毒。食品安全监管的实施取决于对食品中抗菌剂残留的有效监测。在本综述中,我们探讨了肉鸡体内药物残留的快速检测方法。
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Study on Rapid, Quantitative, and Simultaneous Detection of Drug Residues and Immunoassay in Chickens.

Different levels of residual drugs can be monitored within a relatively safe range without causing harm to human health if the appropriate dosing methodology is considered and the drug withdrawal period is controlled during poultry and livestock raising. Antimicrobials are factors that can suppress the growth of microorganisms, and antibiotic residues in livestock farming have been considered as a potential cause of antimicrobial resistance in animals and humans. Antimicrobial drug resistance is associated with the capability of a microorganism to survive the inhibitory effects of the antimicrobial components. Antibiotic residue presence in chicken is a human health concern due to its negative effects on consumer health. Neglected aspects related to the application of veterinary drugs may threaten the safety of both humans and animals, as well as their environment. The detection of chemical contaminants is essential to ensure food quality. The most important antibiotic families used in veterinary medicines are β-lactams (penicillins and cephalosporins), tetracyclines, chloramphenicols, macrolides, spectinomycin, lincosamide, sulphonamides, nitrofuranes, nitroimidazoles, trimethoprim, polymyxins, quinolones, and macrocyclics (glycopeptides, ansamycins, and aminoglycosides). Antibiotic residue presence is the main contributor to the development of antibiotic resistance, which is considered a chief concern for both human and animal health worldwide. The incorrect application and misuse of antibiotics carry the risk of the presence of residues in the edible tissues of the chicken, which can cause allergies and toxicity in hypersensitive consumers. The enforcement of the regulation of food safety depends on efficacious monitoring of antimicrobial residues in the foodstuff. In this review, we have explored the rapid detection of drug residues in broilers.

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来源期刊
Reviews on recent clinical trials
Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-
CiteScore
3.10
自引率
5.30%
发文量
44
期刊介绍: Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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