结直肠癌中 PD-1 和 PD-L1 蛋白表达与部分临床和形态学参数的关系。

IF 0.7 4区 医学 Q4 PATHOLOGY Polish Journal of Pathology Pub Date : 2024-01-01 DOI:10.5114/pjp.2024.139935
Paulina Poter, Sylwia Jankowska-Szabłowska, Tomasz Kolenda, Ewa Dobak, Elżbieta Urasińska, Katarzyna Karpińska-Łukaszewicz
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引用次数: 0

摘要

大肠癌是全球第三大常见癌症,也是恶性肿瘤的第二大死因。结直肠癌的治疗方法包括手术、化疗、基因治疗和免疫治疗。最近,PD-1 和 PD-L1 蛋白被认为是结直肠癌抗癌治疗的潜在靶点。本研究旨在评估结直肠癌患者 PD-1 和 PD-L1 蛋白的免疫组化表达与部分临床和形态学参数及其生存期的关系。研究对象为 98 例结直肠癌患者。研究采用免疫组化方法评估 PD-1 和 PD-L1 蛋白的表达。结果发现,淋巴细胞中 PD-L1 蛋白的表达与无淋巴结转移和较低的临床分期之间存在相关性。癌细胞中 PD-L1 蛋白的表达与组织学恶性程度较高也有相关性。
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Association of PD-1 and PD-L1 protein expression with selected clinical and morphological parameters in colorectal cancers.

Colorectal cancer is the third most common cancer worldwide and the second cause of death from malignant tumors. Colorectal cancers are treated with surgery, chemotherapy, gene therapy and immunotherapy. PD-1 and PD-L1 proteins have recently been considered as potential targets of anticancer therapy in colorectal cancer. The aim of this study was to evaluate the association of immunohistochemical expression of PD-1 and PD-L1 proteins in colorectal cancer patients with selected clinical and morphological parameters and their survival. Ninety-eight cases of colorectal cancer were studied. Immunohistochemistry was used to evaluate the expression of PD-1 and PD-L1 proteins. Correlations were found between the expression of PD-L1 protein in lymphocytes and lack of lymph node metastases and a lower clinical stage. There was also a correlation between PD-L1 protein expression in cancer cells and a higher grade of histological malignancy.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
21
审稿时长
>12 weeks
期刊介绍: Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.
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