UPCARE:尿液细胞外囊泡衍生的前列腺癌风险评估。

IF 15.5 1区 医学 Q1 CELL BIOLOGY Journal of Extracellular Vesicles Pub Date : 2024-08-22 DOI:10.1002/jev2.12491
Shaoqin Jiang, Feiting Lu, Jiadi Chen, Yingzhen Jiao, Qingqing Qiu, Xinwen Nian, Min Qu, Yan Wang, Mengqiang Li, Fei Liu, Xu Gao
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摘要

在寻求通过液体活检进行高效肿瘤诊断的过程中,细胞外囊泡 (EV) 已显示出作为潜在生物标记物来源的前景。本研究针对中西方人群在预测具有临床意义的前列腺癌(csPCa)的生物标志物功效方面存在的差距进行了研究。我们利用 EXODUS 技术从 598 名患者体内分离出尿细胞外囊泡,并结合 FOXA1、PCA3 和 KLK3 的基因表达,建立了基于尿细胞外囊泡的前列腺评分(EPS)模型。我们的研究结果表明,在 234 名患者的训练队列中,EPS 模型的诊断准确性超过了前列腺特异性抗原(PSA)检测,其曲线下面积(AUC)为 0.730,而 PSA 为 0.659(p = 0.018)。同样,在由 101 名男性组成的验证队列中,EPS 模型的曲线下面积(AUC)为 0.749,明显优于 PSA 的 0.577(p = 0.018)。
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UPCARE: Urinary Extracellular Vesicles-Derived Prostate Cancer Assessment for Risk Evaluation

In the quest for efficient tumor diagnosis via liquid biopsy, extracellular vesicles (EVs) have shown promise as a source of potential biomarkers. This study addresses the gap in biomarker efficacy for predicting clinically significant prostate cancer (csPCa) between the Western and Chinese populations. We developed a urinary extracellular vesicles-based prostate score (EPS) model, utilizing the EXODUS technique for EV isolation from 598 patients and incorporating gene expressions of FOXA1, PCA3, and KLK3. Our findings reveal that the EPS model surpasses prostate-specific antigen (PSA) testing in diagnostic accuracy within a training cohort of 234 patients, achieving an area under the curve (AUC) of 0.730 compared to 0.659 for PSA (= 0.018). Similarly, in a validation cohort of 101 men, the EPS model achieved an AUC of 0.749, which was significantly better than PSA's 0.577 (< 0.001). Our model has demonstrated a potential reduction in unnecessary prostate biopsies by 26%, with only a 3% miss rate for csPCa cases, indicating its effectiveness in the Chinese population.

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来源期刊
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
27.30
自引率
4.40%
发文量
115
审稿时长
12 weeks
期刊介绍: The Journal of Extracellular Vesicles is an open access research publication that focuses on extracellular vesicles, including microvesicles, exosomes, ectosomes, and apoptotic bodies. It serves as the official journal of the International Society for Extracellular Vesicles and aims to facilitate the exchange of data, ideas, and information pertaining to the chemistry, biology, and applications of extracellular vesicles. The journal covers various aspects such as the cellular and molecular mechanisms of extracellular vesicles biogenesis, technological advancements in their isolation, quantification, and characterization, the role and function of extracellular vesicles in biology, stem cell-derived extracellular vesicles and their biology, as well as the application of extracellular vesicles for pharmacological, immunological, or genetic therapies. The Journal of Extracellular Vesicles is widely recognized and indexed by numerous services, including Biological Abstracts, BIOSIS Previews, Chemical Abstracts Service (CAS), Current Contents/Life Sciences, Directory of Open Access Journals (DOAJ), Journal Citation Reports/Science Edition, Google Scholar, ProQuest Natural Science Collection, ProQuest SciTech Collection, SciTech Premium Collection, PubMed Central/PubMed, Science Citation Index Expanded, ScienceOpen, and Scopus.
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