健康对照组和帕金森病患者的临床评估和纹状体多巴胺能活动:贝叶斯方法。

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Annals of Nuclear Medicine Pub Date : 2024-08-27 DOI:10.1007/s12149-024-01972-y
Seunghyeon Shin, Hyun-Yeol Nam, Keunyoung Kim, Jihyun Kim, Myung Jun Lee, Kyoungjune Pak
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引用次数: 0

摘要

目的我们旨在评估帕金森病(PD)患者和健康对照组纹状体多巴胺转运体(DAT)摄取量与临床评估之间的相关性:本研究招募了 193 名健康对照者和 581 名帕金森病患者。他们接受了各种临床评估和 123I-FP-CIT SPECT 扫描。在对 SPECT 图像进行重建、衰减校正和归一化处理后,测量了双侧尾状核、普鲁士门和枕叶皮层的计数。提取每个区域的计数密度并用于计算每个纹状体区域的纹状体结合率(SBR)。SBR 的计算公式为(目标区域/参照区域)-1。纹状体结合率对数变换后,我们使用贝叶斯层次模型分析了临床评估对纹状体结合率的影响:结果:MDS-UPDRS总分、第一部分、第二部分、第三部分、埃普沃斯嗜睡量表、快速眼动睡眠行为障碍筛查问卷、SCOPA-AUT总分与帕金森病患者纹状体SBR呈负相关。此外,在健康对照组和帕金森病患者中,HVLT识别辨别能力与纹状体SBR呈正相关。在健康对照组中,MDS-UPDRS 第二部分、MOCA、SCOPA-AUT 总分与纹状体 SBR 呈正相关:我们的研究表明,帕金森病患者的运动症状、睡眠障碍、自主神经症状和认知能力与纹状体多巴胺能活动有关。在健康对照组中,运动症状、自主神经症状和认知能力与纹状体多巴胺能活动相关,其中一些与帕金森病患者的多巴胺能活动方向相反。这一结果可能为多巴胺系统与运动和非运动评估的内在机制提供了新的见解。
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Clinical assessment and striatal dopaminergic activity in healthy controls and patients with Parkinson’s disease: a Bayesian approach

Objectives

We aimed to evaluate correlations between striatal dopamine transporter (DAT) uptake and clinical assessments in both patients with Parkinson’s disease (PD) and healthy controls.

Methods

This study enrolled 193 healthy controls, and 581 patients with PD. They underwent various clinical assessments and 123I-FP-CIT SPECT scans. After reconstruction, attenuation correction, and normalization of SPECT images, counts were measured from the bilateral caudate and putamen, and the occipital cortex for reference. Count densities for each region were extracted and used to calculate striatal binding ratios (SBRs) for each striatal region. SBR is calculated as (target region/reference region)—1. After logarithmic transformation of striatal SBRs, we analyzed the effects of clinical assessments on striatal SBRs using Bayesian hierarchical modeling.

Results

MDS-UPDRS total score, part I, part II, part III, Epworth Sleepiness Scale, REM sleep behavior disorder screening questionnaire, SCOPA-AUT total score were negatively associated with striatal SBR in patients with PD. Also, HVLT recognition discrimination was positively associated with striatal SBR in both healthy controls and patients with PD. In healthy control, MDS-UPDRS part II, MOCA, SCOPA-AUT total score were positively associated with striatal SBR.

Conclusion

We demonstrated that motor symptom, sleep disturbance, autonomic symptom, and cognition of patients with PD were associated with striatal dopaminergic activity. In healthy controls, motor symptoms, autonomic symptom, and cognition were associated with striatal dopaminergic activity, some of which showing the opposite direction with patients with PD. This result might provide new insight to underlying mechanism of dopamine system with motor and non-motor assessments.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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