生姜提取物对双酚 A 诱导的成年雄性白化大鼠甲状腺毒性变化的可能保护作用:光镜和电子显微镜研究。

IF 1.1 4区 医学 Q4 MICROSCOPY Ultrastructural Pathology Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI:10.1080/01913123.2024.2395849
Sara Mohammed Taha Denewer, Safinaz Moustafa Mahmoud Ali, Nawal Awad Hasanin, Dalia Refat El-Bassouny
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引用次数: 0

摘要

双酚 A(BPA)是一种用于塑料工业的化学物质,被认为是一种内分泌干扰物。生姜是一种用于食品工业的草药,具有抗氧化活性。本研究旨在评估成年雄性白化大鼠摄入双酚 A 后甲状腺的组织学变化,以及生姜提取物(GE)是否具有保护作用。研究人员将 80 只成年雄性大鼠平均分为四组。第一组为对照组,第二组大鼠每天口服 250 毫克/千克生姜提取物,连续八周;第三组大鼠每天口服 200 毫克/千克双酚 A,连续八周;第四组大鼠在口服相同剂量双酚 A 的同时口服生姜提取物,连续八周。实验结束后,对大鼠的血液样本进行激素分析,并对组织样本进行处理。进行了光镜和电子显微镜研究。进行了形态计量学和统计学研究。第三组显示甲状腺发生了退行性变化,血清中的T3和T4水平下降,诱导型一氧化氮合酶(iNOS)免疫反应呈强阳性。第四组则显示出甲状腺结构和功能的恢复。总之,通用电气通过抗氧化作用保护甲状腺结构免受双酚 A 氧化应激的破坏,从而保持甲状腺的活性。
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The possible protective effect of ginger extract on toxic changes induced by bisphenol A on the thyroid gland of adult male albino rats: light and electron microscopic study.

Bisphenol A (BPA) is a chemical substance used in the plastic industry and considered as an endocrine disruptor. Ginger is a herbal material used in the food industry and has antioxidant activity. The present study was performed to evaluate the histological changes in the thyroid gland of adult male albino rats after intake of BPA and if there is any protective role for ginger extract (GE). Eighty adult male rats were divided equally into four groups. Group I as a control group, group II included rats that received 250 mg/kg/day GE orally for eight weeks, group III included rats that received 200 mg/kg/day BPA orally for the same period and group IV included rats that received BPA in the same dose for the same duration concomitantly with GE. At the end of the experiment, blood samples were taken for hormonal essay and tissue samples were processed. Light and electron microscopic studies were done. Morphometric and statistical studies were carried out. Group III showed degenerative changes in the thyroid gland, decreased serum levels of T3 and T4 and a strong positive inducible nitric oxide synthase (iNOS) immune response. Group IV showed restoration of thyroid gland architecture and function. In conclusion, GE protected the thyroid structure from the damaging effect of BPA oxidative stress through its anti-oxidant effect, thus preserving thyroid activity.

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来源期刊
Ultrastructural Pathology
Ultrastructural Pathology 医学-病理学
CiteScore
2.00
自引率
10.00%
发文量
40
审稿时长
6-12 weeks
期刊介绍: Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.
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