血清和糖皮质激素调节激酶 1 (SGK1) 作为心脏疾病的新兴治疗靶点

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological research Pub Date : 2024-08-28 DOI:10.1016/j.phrs.2024.107369

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引用次数: 0

摘要

心脏病包括一系列影响心脏结构和功能的疾病。这些疾病是全球发病率和死亡率的主要原因。血清和糖皮质激素诱导激酶 1（SGK1）是一种丝氨酸/苏氨酸激酶，在细胞存活和应激反应等多种细胞过程中发挥着重要作用。SGK1 活性的改变会对健康和疾病产生重大影响。多项研究结果表明，SGK1 与心脏病有关，因为它参与了心脏肥大和纤维化。本文综述了在各种心脏疾病中与 SGK1 活性相关的不同信号通路，包括 SGK1/NF-κB 和 PI3K/SGK1 通路。

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Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases

Cardiac diseases encompass a wide range of conditions that affect the structure and function of the heart. These conditions are a leading cause of morbidity and mortality worldwide. The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell survival and stress response. Alterations in SGK1 activity can have significant impacts on health and disease. Multiple research findings have indicated that SGK1 is associated with heart disease due to its involvement in cardiac hypertrophy and fibrosis. This article reviews different signaling pathways associated with SGK1 activity in various heart conditions, including the SGK1/NF-κB and PI3K/SGK1 pathways.

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.