转基因植物和重组微生物在生产特殊脂肪酸方面的生物技术进步

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-08-28 DOI:10.1016/j.biotechadv.2024.108435
Juli Wang , Stacy D. Singer , Guanqun Chen
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引用次数: 0

摘要

某些植物和微生物能产生大量的非正常脂肪酸(UFAs),如羟基、共轭、环状和超长链多不饱和脂肪酸,它们具有独特的物理化学特性,在食品、饲料和油脂化学工业中有着重要的应用。由于许多天然来源的超不饱和脂肪酸并不适合大规模农业生产或发酵,因此通过合成生物学生产这些物质具有吸引力。虽然转基因植物和微生物已经商业化或预商业化生产出了几种 UFAs,但它们在转基因宿主中的含量通常比天然来源的要低得多。此外,要在更广泛的 UFAs 领域再现这种成功仍然具有挑战性。本综述讨论了我们对 UFAs 的生物合成、积累和异源生产的最新理解进展,并探讨了在工程植物和微生物中实现高 UFA 含量所面临的挑战和潜在策略。
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Biotechnological advances in the production of unusual fatty acids in transgenic plants and recombinant microorganisms

Certain plants and microorganisms can produce high amounts of unusual fatty acids (UFAs) such as hydroxy, conjugated, cyclic, and very long-chain polyunsaturated fatty acids, which have distinct physicochemical properties and significant applications in the food, feed, and oleochemical industries. Since many natural sources of UFAs are not ideal for large-scale agricultural production or fermentation, it is attractive to produce them through synthetic biology. Although several UFAs have been commercially or pre-commercially produced in transgenic plants and microorganisms, their contents in transgenic hosts are generally much lower than in natural sources. Moreover, reproducing this success for a wider spectrum of UFAs has remained challenging. This review discusses recent advancements in our understanding of the biosynthesis, accumulation, and heterologous production of UFAs, and addresses the challenges and potential strategies for achieving high UFA content in engineered plants and microorganisms.

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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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