局部疗法联合免疫检查点抑制剂治疗肝转移。

IF 5.3 2区 医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-08-31 DOI:10.1186/s12935-024-03484-1
Xing-Chen Zhang, Yu-Wen Zhou, Gui-Xia Wei, Yi-Qiao Luo, Meng Qiu
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引用次数: 0

摘要

免疫检查点抑制剂(ICIs)在临床研究和实践中取得了令人瞩目的成就。值得注意的是,肝转移对 ICIs 并不敏感。肝脏局部治疗可对肿瘤细胞造成不可逆损伤并释放肿瘤抗原,从而为肝转移的免疫治疗提供了理论依据。ICIs 与局部治疗的联合疗法是肝转移患者的一个很有前景的选择。临床前研究表明,将 ICIs 与局部治疗相结合可产生显著的协同抗肿瘤效果。然而,目前有关 ICIs 与局部治疗相结合的疗效证据仍然不足。因此,我们回顾了有关局部区域疗法治疗肝转移的机制及其与 ICIs 联用的临床研究进展的文献。
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Locoregional therapies combined with immune checkpoint inhibitors for liver metastases.

Immune checkpoint inhibitors (ICIs) have achieved remarkable success in clinical research and practice. Notably, liver metastasis is not sensitive to ICIs. Liver locoregional therapies can cause irreversible damage to tumor cells and release tumor antigens, thereby providing a rationale for immunotherapy treatments in liver metastasis. The combination therapy of ICIs with locoregional therapies is a promising option for patients with liver metastasis. Preclinical studies have demonstrated that combining ICIs with locoregional therapies produces a significantly synergistic anti-tumor effect. However, the current evidence for the efficacy of ICIs combined with locoregional therapies remains insufficient. Therefore, we review the literature on the mechanisms of locoregional therapies in treating liver metastasis and the clinical research progress of their combination with ICIs.

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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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