交变磁场引导系统,用于 MNP 热疗治疗深部癌症。

IF 3 3区 医学 Q2 ONCOLOGY International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-08-29 DOI:10.1080/02656736.2024.2391008
Robert V Stigliano, Ilona Danelyan, Giga Gabriadze, Levan Shoshiashvili, Ian Baker, P Jack Hoopes, Roman Jobava, Fridon Shubitidze
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引用次数: 0

摘要

目标:展示一种类似内窥镜的新型装置的潜在应用,该装置可引导和聚焦交变磁场(AMF),通过磁性纳米粒子热疗(MNPH)治疗深层癌症:方法:通过人体模型的实验研究和全三维人体模型的计算模拟,对交变磁场的输送、磁性纳米粒子的激活和涡流分布特性进行了研究。三维模拟将新型设备与传统的 AMF 设计(包括类似 MagForce 的双线圈系统(临床使用)和单表面线圈系统)进行了比较:结果表明,这种方法可以在前列腺中心点提供与传统 AMF 设计相同的磁场强度,同时将涡流加热降低 2 到 6 倍。在相同的正常组织加热水平下,这种方法为前列腺的最近、中心和最远区域提供的磁场强度分别为 5.0 倍、1.5 倍和 0.92 倍:这些结果证明了内窥镜磁场引导和聚焦系统的概念,该系统能够远距离提供临床相关的 AMF。这种创新方法通过引导 AMF 穿过身体、将其集中在肿瘤区域、减少周围健康组织中的涡流以及避免附近金属植入物的暴露,为传统磁场传输方法提供了一种很有前景的替代方法。
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Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers.

Objectives: Demonstrate the potential application of a novel, endoscope-like device to guide and focus an alternating magnetic field (AMF) for treating deep-seated cancers via magnetic nanoparticle hyperthermia (MNPH).

Methods: AMF delivery, MNP activation, and eddy current distribution characteristics are investigated through experimental studies in phantoms and computational simulations using a full 3-dimensional human model. The 3D simulations compare the novel device to traditional AMF designs, including a MagForce-like, two-coil system (used clinically) and a single surface-coil system.

Results: The results demonstrate that this approach can deliver the same magnetic field strength at the prostate's centroid as traditional AMF designs, while reducing eddy current heating by 2 to 6 times. At the same level of normal tissue heating, this method provides 5.0 times, 1.5 times, and 0.92 times the magnetic field strength to the nearest, centroid, and farthest regions of the prostate, respectively.

Conclusions: These results demonstrate proof-of-concept for an endoscopic magnetic field guiding and focusing system capable of delivering clinically relevant AMF from a distance. This innovative approach offers a promising alternative to conventional field delivery methods by directing AMF through the body, concentrating it in the tumor region, reducing eddy currents in surrounding healthy tissue, and avoiding exposure of nearby metallic implants.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
期刊最新文献
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