小袋炎治疗现状的重点领域:叙述性综述。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-08-01 DOI:10.30476/ijms.2024.100782.3326
Seyed Mohammad Kazem Hosseini-Asl, Golnoush Mehrabani, Seyed Jalil Masoumi
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引用次数: 0

摘要

肠袋炎是回肠肠袋-肛门吻合术(IPAA)后最常见的并发症,发病率为 7% 至 46%。肠袋炎的治疗仍然是疾病治疗领域最大的知识空白之一。本综述重点介绍了治疗肛门袋炎的成就和挑战。综合评估症状、内窥镜检查结果、组织学结果、快速生物标记物和粪便钙蛋白检测结果被认为是有价值的诊断标准。传统疗法被描述为改变细菌菌群,主要是使用抗生素,最近则使用益生菌,如双歧杆菌、乳酸杆菌和链球菌。还讨论了其他治疗方法,如抗肿瘤坏死因子、英夫利昔单抗、阿达木单抗、维妥珠单抗、乌斯特库单抗、他克莫司、托法替尼、硫嘌呤类药物、皮质类固醇、含脯氨酰羟化酶的酶、聚维酮碘、葡萄糖喷雾剂、粪便微生物群移植、草药和白细胞分离术。除常规疗法外,饮食成分的改变以及补充和替代药物、益生菌和粪便移植的使用也会影响疾病的治疗效果。由于肠袋炎可能会严重影响患者的生活质量,因此必须填补患者和医生在治疗方面的知识空白。因此,应开展设计合理、充分有效的研究,评估治疗胃袋炎的最佳方法。
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Key Focus Areas in Pouchitis Therapeutic Status: A Narrative Review.

Pouchitis, as the most common complication after ileal pouch-anal anastomosis (IPAA), has an incidence from 7% to 46%. Pouchitis treatment still represents one of the biggest gaps of knowledge in the treatment of diseases. This review has focused on achievements and challenges in the treatment of pouchitis. A combined assessment of symptoms, endoscopic findings, histologic results, quick biomarkers, and fecal calprotectin test were determined to be valuable diagnostic criteria. Conventional therapy was described as a modification of bacterial flora, mainly with antibiotics and more recently with probiotics such as bifidobacteria, lactobacilli, and streptococci. Other therapeutic approaches such as anti-tumor necrosis factor, infliximab, adalimumab, vedolizumab, ustekinumab, tacrolimus, tofacitinib, thiopurines, corticosteroids, prolyl hydroxylase-containing enzymes, povidone-iodine, dextrose spray, fecal microbiota transplantation, herbal medicines, and leukocyte apheresis have been discussed. Changes in dietary components, and administration of complementary and alternative medicine, probiotics, and fecal transplantation in addition to conventional therapies were also shown to affect the outcome of disease. Due to the potential significant impairment in quality of life caused by pouchitis, it is essential to address the gaps in knowledge for both patients and physicians in its treatment. Therefore, well-designed and adequately powered studies should assess the optimal treatment for pouchitis.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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