对亨廷顿氏病日常功能(Hi-DEF)进行拉施测量理论(RMT)分析,以评估项目拟合度和性能。

IF 2.1 Q3 NEUROSCIENCES Journal of Huntington's disease Pub Date : 2024-01-01 DOI:10.3233/JHD-240001
Jennifer Petrillo, Ruta Sawant, Emma Elliott, Sophie Cleanthous, Rebecca Rogers, Stefan Cano, Sarah Baradaran, Jason Johannesen
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引用次数: 0

摘要

背景:亨廷顿氏病(HD)日常功能(Hi-DEF)是一种新的患者报告结果(PRO)工具,旨在测量HD早期阶段认知障碍对日常功能的影响:评估 Hi-DEF 的测量特性并最终确定项目内容:方法:在美国 9 家高级研究中心对早期 HD 患者进行横断面观察心理测量验证研究。对Hi-DEF的初稿(47个项目)和子量表(即 "家庭"、"工作"、"驾驶 "和 "沟通")进行了拉施测量理论(RMT)分析,以检查测量特性,包括样本到量表的目标性、反应量表的适宜性(反应阈值的排序)、量表的内聚性(项目拟合)、局部独立性和个体拟合:共纳入 151 名参与者(平均年龄 47 岁(SD 12),59% 为女性)。根据依赖性和项目契合度删除了 7 个项目。剩下的 40 个项目的 Hi-DEF 显示出良好的测量特性。在四个分量表中,目标定位范围为 49%-70%(全量表为 72%),通过人与人之间的分离指数确定的信度范围为 0.53-0.87(全量表为 0.92),25%-100% 的项目(全量表为 75%)的反应量表是有序的,0%-12% 的项目显示出不匹配(全量表为 2%),0%-1% 的项目对(全量表为 2%)显示出依赖性:我们的研究证明,Hi-DEF 是一种可靠、有效的新的 PRO 工具,旨在评估认知障碍对 HD 早期患者日常功能的影响。未来的工作将评估其外部效度和在临床试验中的应用。
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Rasch Measurement Theory (RMT) Analyses of the Huntington's Disease Everyday Functioning (Hi-DEF) to Evaluate Item Fit and Performance.

Background: The Huntington's Disease (HD) Everyday Functioning (Hi-DEF) is a new patient-reported outcome (PRO) instrument designed to measure the impact of cognitive impairment on daily functioning in the early stages of HD.

Objective: To assess the measurement properties and finalize item content of the Hi-DEF.

Methods: A cross-sectional, observational psychometric validation study was conducted among individuals with early stages of HD at 9 US centers of excellence. Rasch Measurement Theory (RMT) analysis of the initial draft version of the Hi-DEF (47 items) and subscales (i.e., 'Home', 'At work', 'Driving', and 'Communication') was conducted to examine measurement properties including sample-to-scale targeting, suitability of response scale (ordering of response thresholds), scale cohesiveness (item fit), local independence, and person fit.

Results: 151 participants (mean age 47 years (SD 12), 59% female) were included. Seven items were removed based on dependency and item fit. The remaining 40-item version of the Hi-DEF demonstrated good measurement properties. Across the four subscales, targeting ranged from 49-70% (72% full scale), reliability ascertained by person separation index ranged from 0.53-0.87 (0.92 full scale), response scales were ordered for 25-100% of items (75% full scale), 0-12% items displayed misfit (2% full scale), and 0-1% (2% full scale) item pairs displayed dependency.

Conclusions: Our study supports the psychometric integrity of the Hi-DEF as a reliable and valid new PRO instrument designed to assess the impact of cognitive impairment on daily functioning in the early stages of HD. Future work will evaluate the external validity and utility in clinical trial applications.

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CiteScore
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9.70%
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60
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