通过 Rh(III)-Catalyzed [3 + 2]-Annulation between Quinoxalines and Alkynylcyclobutanols，用环丁烷构建新型螺环框架。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-09-20 Epub Date: 2024-09-03 DOI:10.1021/acs.joc.4c00505

Yi-Chi Gang, Lin Dong

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引用次数: 0

摘要

我们开发出了一种制备 1'H-螺[茚-1,2'-喹喔啉]的有效合成策略。这涉及到 Rh(III) 催化的喹喔啉与炔基环丁醇的 [3 + 2] 环化反应。所开发的方案为制备具有四元环的多功能杂环化合物提供了一种简单易行的方法，并且与多种官能团兼容。

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The Construction of Novel Spirocyclic Frameworks with Cyclobutane through Rh(III)-Catalyzed [3 + 2]-Annulation between Quinoxalines and Alkynylcyclobutanols.

An effective synthesis strategy for the preparation of 1'H-spiro[indene-1,2'-quinoxaline] has been developed. This involves a Rh(III)-catalyzed [3 + 2]-annulation of quinoxalines with alkynylcyclobutanols. The developed protocol offers a straightforward method for the preparation of versatile heterocyclic compounds with a four-membered ring and is compatible with a wide range of functional groups.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.