{"title":"封面内页图片","authors":"","doi":"10.1002/cjoc.202490192","DOIUrl":null,"url":null,"abstract":"<p>Divergent protein engineering of the natural transaminase Vf-ω-TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% <i>ee</i>). More details are discussed in the article by Zhong <i>et al</i>. on pages 2335—2340.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"42 19","pages":"2274"},"PeriodicalIF":5.5000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202490192","citationCount":"0","resultStr":"{\"title\":\"Inside Cover Picture\",\"authors\":\"\",\"doi\":\"10.1002/cjoc.202490192\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Divergent protein engineering of the natural transaminase Vf-ω-TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% <i>ee</i>). More details are discussed in the article by Zhong <i>et al</i>. on pages 2335—2340.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":151,\"journal\":{\"name\":\"Chinese Journal of Chemistry\",\"volume\":\"42 19\",\"pages\":\"2274\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202490192\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202490192\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202490192","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Divergent protein engineering of the natural transaminase Vf-ω-TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% ee). More details are discussed in the article by Zhong et al. on pages 2335—2340.
期刊介绍：
The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.
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