具有浆液性和结肠直肠癌样成分的高级别子宫内膜癌:独特的形态与免疫组化和分子研究结果的相关性。

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-08-12 DOI:10.1097/PGP.0000000000001067
Marie C Smithgall, Anna Yemelyanova, James Solomon, Eloise Chapman-Davis, Nina Schatz-Siemers
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引用次数: 0

摘要

具有肠道分化/结直肠癌样(CRC-like)特征的子宫内膜癌非常罕见,迄今鲜有报道。所描述的主要是具有肠道分化的子宫内膜样癌。我们报告了一例具有浆液性和肠/CRC样成分的高级别子宫内膜癌。我们描述了最初诊断活检和随后切除标本中两种肿瘤成分的大体、组织学、免疫组化和分子特征。原发性子宫内膜癌伴有浆液性和 CRC 样成分的诊断得到了免疫组化和分子研究结果以及临床检查的支持。这种现象的罕见性为诊断带来了挑战。此外,本文还回顾了相关文献,特别强调了混合型子宫内膜癌(包括具有肠/CRC样特征的子宫内膜癌)的分子和病理特征。
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High-grade Endometrial Carcinoma With Serous and Colorectal Carcinoma-like Components: Unique Morphology in Correlation With Immunohistochemical and Molecular Findings.

Endometrial carcinoma with intestinal differentiation/colorectal carcinoma-like (CRC-like) features is rare with few cases reported to date. Those described are mainly endometrioid carcinomas with intestinal differentiation. We report a case of high-grade endometrial carcinoma with serous and intestinal/CRC-like components. The gross, histologic, immunohistochemical, and molecular features are described for both components of the tumor in the initial diagnostic biopsy and subsequent resection specimen. The diagnosis of primary endometrial carcinoma with serous and CRC-like components is supported by immunohistochemical and molecular findings, as well as clinical workup. The rarity of this phenomenon poses diagnostic challenges. In addition, the literature is reviewed with specific emphasis on the molecular and pathologic features of mixed endometrial carcinomas, including those with intestinal/CRC-like features.

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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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