老龄化研究的临床新时代。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-09-02 DOI:10.1016/j.tem.2024.08.004
Zhen Zhang, Renlei Yang, Zhike Zi, Baohua Liu
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引用次数: 0

摘要

衰老是多种疾病的主要风险因素,因此,将衰老研究转化为实际应用的动力来自于现有临床治疗方案尚未满足的需求。基础研究和转化研究工作正处于一个关键阶段,它们将深入了解如何利用基本衰老机制来确定有前景的老年保护剂或治疗方法。本综述从临床角度重点介绍了几个研究领域,包括靶向衰老细胞、减轻炎症反应以及利用内源性代谢物或前体优化新陈代谢。完善我们对这些关键领域的理解,尤其是从临床角度来看,可能有助于我们更好地理解和减轻衰老过程,改善整体健康状况。
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A new clinical age of aging research.

Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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