甲状旁腺癌的诊断和治疗。

IF 6.3 2区 医学 Q1 PHARMACOLOGY & PHARMACY Clinical Pharmacology & Therapeutics Pub Date : 2024-09-05 DOI:10.1002/cpt.3432
Alexander Lazzaro, Grace (Qing) Zhao, Matthew Kulke
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引用次数: 0

摘要

甲状旁腺癌(PC)是一种罕见的恶性肿瘤,通常以甲状旁腺激素分泌失调为特征。晚期患者通常会因严重的高钙血症以及肿瘤扩散引起的直接并发症而死亡。由于甲状旁腺癌非常罕见,目前还缺乏正式的研究来指导甲状旁腺癌的诊断和治疗。不过,最近来自病例报告、系列病例和登记研究的数据表明,这种研究不足的疾病正在出现新的有效治疗方法。我们回顾了有关甲状旁腺癌诊断和治疗的现有文献。我们的研究结果表明,对局部和转移性疾病进行手术切除等传统方法仍在患者治疗中发挥着重要作用。对于无法切除的患者,包括替莫唑胺和酪氨酸激酶抑制剂在内的新型全身治疗方法可能会带来临床益处。
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Diagnosis and Management of Parathyroid Carcinoma

Parathyroid carcinoma (PC) is a rare malignancy, often characterized by the unregulated secretion of parathyroid hormone. The sequelae of severe hypercalcemia together with direct complications from tumor dissemination in patients with advanced disease are usually fatal. Due to its rarity, formal studies to guide the diagnosis and management of parathyroid carcinoma are lacking. However, recent data from case reports, case series, and registry studies suggest the emergence of new and effective treatment approaches for this understudied disease. We reviewed existing literature on the diagnosis and management of parathyroid carcinoma. Our findings suggest that traditional approaches such as surgical resection for both localized and metastatic diseases continue to play an important role in patient management. For patients with unresectable disease, newer systemic treatment approaches, including the use of temozolomide and tyrosine kinase inhibitors, may offer clinical benefit.

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来源期刊
CiteScore
12.70
自引率
7.50%
发文量
290
审稿时长
2 months
期刊介绍: Clinical Pharmacology & Therapeutics (CPT) is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics. CPT welcomes original Articles in the emerging areas of translational, predictive and personalized medicine; new therapeutic modalities including gene and cell therapies; pharmacogenomics, proteomics and metabolomics; bioinformation and applied systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigation and clinical trials, pharmacovigilence, pharmacoepidemiology, pharmacometrics, and population pharmacology.
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