一匹马患急性髓性白血病-M1,伴有神经症状和坏死性小肠结肠炎。

IF 1.2 3区 农林科学 Q3 VETERINARY SCIENCES Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI:10.1177/10406387241268322
Jeongha Lee, Sydney Mordoh, Mustajab Mirza, Mariano Carossino, Fabio Del Piero
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引用次数: 0

摘要

一匹 18 岁的美国鞍马因发烧和急性神经症状入院,症状包括共济失调 5 级中的 3 级、前倾困难和精神迟钝。由于经济拮据,无法进行所需的检测;尽管进行了支持性治疗,但该马的病情仍在恶化,因此选择了安乐术。死后检查发现,马的脑膜和脑神经膜上有瘀斑和瘀点。在神经实质、肠粘膜下层和其他器官(包括肝脏、肾脏、肺部和肠系膜淋巴结)的血管和出血区发现了爆炸样肿瘤性圆形细胞。此外,还发现了坏死性小肠结肠炎和急性纤维蛋白溶解性细菌性肺炎。在脑部的非典型圆形细胞中,70%以上表达离子化钙结合适配器分子 1(Iba1),10%-20%表达髓过氧化物酶(MPO),以及
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Acute myeloid leukemia-M1 in a horse with neurologic signs and necrotizing enterocolitis.

An 18-y-old American Saddlebred mare was admitted with fever and acute onset of neurologic signs including grade 3 of 5 ataxia, difficulty in prehension, and dull mentation. Because of financial restraints, desired testing could not be performed; the horse's condition declined despite supportive treatment, and euthanasia was elected. Postmortem examination revealed petechiae and ecchymoses in the meninges and neuroparenchyma of the encephalon. Blast-like neoplastic round cells were identified within the vasculature and areas of hemorrhage in the neuroparenchyma, the intestinal submucosa, and other organs, including the liver, kidney, lung, and mesenteric lymph node. Necrotizing enterocolitis and acute fibrinonecrotizing bacterial pneumonia were also noted. Of the atypical round cells in the encephalon, >70% expressed ionized calcium-binding adapter molecule 1 (Iba1), 10-20% expressed myeloperoxidase (MPO), and <10% expressed PAX5, CD3, CD20, CD79a, or MUM1. The bone marrow was diffusely effaced by neoplastic round cells expressing Iba1, and ~70% of these cells expressed MPO with no expression of CD3 or CD20. CD172a also immunolabeled a portion of the neoplastic cells. These findings were consistent with the diagnosis of acute myeloid leukemia-M1 with an unusual neurologic presentation.

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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
127
审稿时长
6-16 weeks
期刊介绍: The Journal of Veterinary Diagnostic Investigation (J Vet Diagn Invest) is an international peer-reviewed journal published bimonthly in English by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). JVDI is devoted to all aspects of veterinary laboratory diagnostic science including the major disciplines of anatomic pathology, bacteriology/mycology, clinical pathology, epidemiology, immunology, laboratory information management, molecular biology, parasitology, public health, toxicology, and virology.
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