比较各种木瓜蛋白酶酶制剂和 2.4% 次氯酸钠凝胶在化学机械除龋中的功效:随机对照试验。

IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE BDJ Open Pub Date : 2024-09-04 DOI:10.1038/s41405-024-00258-9
M H D Baraa Alsayed, Mawia Karkoutly, Hassan Achour, Souad Abboud
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引用次数: 0

摘要

研究目的本研究旨在评估和比较Papacarie Duo凝胶、Brix 3000、Selecti-Solve凝胶、2.4%次氯酸钠凝胶和传统旋转机械法在去除龋齿方面的疗效,并评估患者的舒适度:这是一项单盲、随机、平行组、主动对照试验,共有五组。试验在大马士革大学牙体修复和牙髓病学系进行。75例标本被随机分配到五组:使用Selecti-Solve凝胶(G1)、BRIX3000(G2)、Papacarie DUO凝胶(G3)或2.4%次氯酸钠凝胶(G4)的化学机械除龋(CMCR)组,以及使用传统旋转机械方法的龋齿挖掘组(G5)(对照组)。试验对象为 18-40 岁的健康患者。试验对象包括Ⅰ类龋坏扩展至牙本质中三分之一处且无牙髓和/或牙周病变的恒磨牙患者。龋齿去除的疗效被认为是主要结果指标,次要结果指标是治疗时间、龋洞体积测量和疼痛评估:结果:BRIX3000 和传统旋转机械法组的大多数病例(73.30%)显示龋齿完全清除(P = 0.982)。2.4% 次氯酸钠凝胶组的平均除龋时间最长(17.45 ± 4.42)(p 结论:BRIX3000 和传统旋转机械法组的平均除龋时间最长(17.45 ± 4.42):考虑到工作时间较长,CMCR 药剂有可能替代传统的旋转器械方法。
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Comparing efficacies of various papain-based enzyme agents and 2.4% sodium hypochlorite gel in chemomechanical caries removal: a randomized controlled trial.

Objective: This study aimed to evaluate and compare the efficacies of Papacarie Duo gel, Brix 3000, Selecti-Solve gel, 2.4% sodium hypochlorite gel, and conventional rotary-mechanical method in caries removal and to evaluate the patient comfort.

Methods: It was a single-blinded, randomized, parallel-group, active-controlled trial with five arms. It was conducted at the Department of Restorative Dentistry and Endodontics, Damascus University. Seventy-five specimens were randomly allocated into five groups: chemomechanical caries removal (CMCR) using Selecti-Solve gel (G1), BRIX3000 (G2), Papacarie DUO gel (G3), or 2.4% sodium hypochlorite gel (G4), and caries excavation using conventional rotary-mechanical method (G5) (control group). The trial considered healthy patients aged 18-40. Permanent molars with class I carious lesions extending to the middle third of dentin with no pulpal and/or periodontal pathology were included. The efficacy of caries removal was considered the primary outcome measure, and the secondary outcome measures were treatment time, volumetric measurement of the cavity, and pain assessment.

Results: The majority (73.30%) of cases from BRIX3000 and conventional rotary-mechanical method groups showed complete caries removal (p = 0.982). The mean time of caries removal was the highest (17.45 ± 4.42) in the 2.4% sodium hypochlorite gel group (p < 0.05), and the lowest (6.33 ± 1.69) was in the conventional rotary-mechanical method group (p < 0.05). The mean cavity volume was the highest (18.97 ± 9.76) in the Papacarie DUO gel group, and the lowest (14.87 ± 4.76) was in the 2.4% sodium hypochlorite gel group (p = 0.506). The conventional rotary-mechanical group exhibited the highest mean score (5.40 ± 1.72) of pain (p < 0.05). However, the mean score (2.67 ± 1.11) of pain reported reduced in the BRIX3000 group.

Conclusions: CMCR agents could be a potential substitute for conventional rotary instrumentation methods, taking into account the long working time.

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来源期刊
BDJ Open
BDJ Open Dentistry-Dentistry (all)
CiteScore
3.70
自引率
3.30%
发文量
34
审稿时长
30 weeks
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