{"title":"创伤性脑损伤的神经免疫和神经炎症反应。","authors":"","doi":"10.1016/j.brainresbull.2024.111066","DOIUrl":null,"url":null,"abstract":"<div><p>Traumatic brain injury (TBI) is one of the major diseases leading to mortality and disability, causing a serious disease burden on individuals' ordinary lives as well as socioeconomics. In primary injury, neuroimmune and neuroinflammation are both responsible for the TBI. Besides, extensive and sustained injury induced by neuroimmune and neuroinflammation also prolongs the course and worsens prognosis of TBI. Therefore, this review aims to explore the role of neuroimmune, neuroinflammation and factors associated them in TBI as well as the therapies for TBI. Thus, we conducted by searching PubMed, Scopus, and Web of Science databases for articles published between 2010 and 2023. Keywords included “traumatic brain injury,” “neuroimmune response,” “neuroinflammation,” “astrocytes,” “microglia,” and “NLRP3.” Articles were selected based on relevance and quality of evidence. On this basis, we provide the cellular and molecular mechanisms of TBI-induced both neuroimmune and neuroinflammation response, as well as the different factors affecting them, are introduced based on physiology of TBI, which supply a clear overview in TBI-induced chain-reacting, for a better understanding of TBI and to offer more thoughts on the future therapies for TBI.</p></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0361923024002004/pdfft?md5=6d5111292395616611cec04b934b5fae&pid=1-s2.0-S0361923024002004-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Neuroimmune and neuroinflammation response for traumatic brain injury\",\"authors\":\"\",\"doi\":\"10.1016/j.brainresbull.2024.111066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Traumatic brain injury (TBI) is one of the major diseases leading to mortality and disability, causing a serious disease burden on individuals' ordinary lives as well as socioeconomics. In primary injury, neuroimmune and neuroinflammation are both responsible for the TBI. Besides, extensive and sustained injury induced by neuroimmune and neuroinflammation also prolongs the course and worsens prognosis of TBI. Therefore, this review aims to explore the role of neuroimmune, neuroinflammation and factors associated them in TBI as well as the therapies for TBI. Thus, we conducted by searching PubMed, Scopus, and Web of Science databases for articles published between 2010 and 2023. Keywords included “traumatic brain injury,” “neuroimmune response,” “neuroinflammation,” “astrocytes,” “microglia,” and “NLRP3.” Articles were selected based on relevance and quality of evidence. On this basis, we provide the cellular and molecular mechanisms of TBI-induced both neuroimmune and neuroinflammation response, as well as the different factors affecting them, are introduced based on physiology of TBI, which supply a clear overview in TBI-induced chain-reacting, for a better understanding of TBI and to offer more thoughts on the future therapies for TBI.</p></div>\",\"PeriodicalId\":9302,\"journal\":{\"name\":\"Brain Research Bulletin\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0361923024002004/pdfft?md5=6d5111292395616611cec04b934b5fae&pid=1-s2.0-S0361923024002004-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain Research Bulletin\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0361923024002004\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0361923024002004","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
创伤性脑损伤(TBI)是导致死亡和残疾的主要疾病之一,对个人的正常生活和社会经济造成严重的疾病负担。在原发性损伤中,神经免疫和神经炎症都是造成创伤性脑损伤的原因。此外,神经免疫和神经炎症诱发的广泛和持续性损伤也会延长创伤性脑损伤的病程并恶化其预后。因此,本综述旨在探讨神经免疫、神经炎症及其相关因素在创伤性脑损伤中的作用,以及创伤性脑损伤的治疗方法。因此,我们在 PubMed、Scopus 和 Web of Science 数据库中搜索了 2010 年至 2023 年间发表的文章。关键词包括 "创伤性脑损伤"、"神经免疫反应"、"神经炎症"、"星形胶质细胞"、"小胶质细胞 "和 "NLRP3"。文章根据相关性和证据质量进行筛选。在此基础上,我们以创伤性脑损伤的生理学为基础,介绍了创伤性脑损伤诱发神经免疫和神经炎症反应的细胞和分子机制,以及影响它们的不同因素,对创伤性脑损伤诱发的连锁反应进行了清晰的概述,以便更好地理解创伤性脑损伤,并为创伤性脑损伤的未来治疗提供更多的思路。
Neuroimmune and neuroinflammation response for traumatic brain injury
Traumatic brain injury (TBI) is one of the major diseases leading to mortality and disability, causing a serious disease burden on individuals' ordinary lives as well as socioeconomics. In primary injury, neuroimmune and neuroinflammation are both responsible for the TBI. Besides, extensive and sustained injury induced by neuroimmune and neuroinflammation also prolongs the course and worsens prognosis of TBI. Therefore, this review aims to explore the role of neuroimmune, neuroinflammation and factors associated them in TBI as well as the therapies for TBI. Thus, we conducted by searching PubMed, Scopus, and Web of Science databases for articles published between 2010 and 2023. Keywords included “traumatic brain injury,” “neuroimmune response,” “neuroinflammation,” “astrocytes,” “microglia,” and “NLRP3.” Articles were selected based on relevance and quality of evidence. On this basis, we provide the cellular and molecular mechanisms of TBI-induced both neuroimmune and neuroinflammation response, as well as the different factors affecting them, are introduced based on physiology of TBI, which supply a clear overview in TBI-induced chain-reacting, for a better understanding of TBI and to offer more thoughts on the future therapies for TBI.
期刊介绍:
The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.