{"title":"设计和合成两种新的硫腙基席夫碱镍 (II) 金属配合物：DNA 结合研究和细胞毒性特征分析","authors":"","doi":"10.1016/j.ica.2024.122337","DOIUrl":null,"url":null,"abstract":"<div><p>Two new nickel (II) substituted thiosemicarbazone Schiff base complexes [Ni(meph)<sub>2</sub>] (1) [where H<sub>2</sub>meph = (2E)-<em>N</em>-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine-1-carbothioamide] and [Ni(hmm)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O (2) [where H<sub>2</sub>hmm = (2E)-2-[(2-hydroxyphenyl)methylidene]-<em>N</em>-methylhydrazine-1-carbothioamide] have been designed and synthesized by the condensation of 4-methyl-3-thiosemicarbazide with 2-acetylpyridine and salicylaldehyde respectively. Both the metal complexes <strong>1</strong> and <strong>2</strong> are characterized using different available spectroscopic techniques like FT-IR, UV–Vis spectroscopy, elemental analysis, and single crystal X-ray structure analysis. X-ray crystal structure analysis reveal that complex <strong>1</strong> and <strong>2</strong> are octahedral Ni(II) complexes. The calf-thymus CT-DNA-binding property of <strong>1</strong> and <strong>2</strong> has been evaluated by employing UV–Vis and fluorescence spectral titration. All the results show that CT-DNA binds with both nickel(II) complexes <strong>1</strong> and <strong>2</strong>. In vitro cytotoxicity activity of complexes <strong>1</strong> and <strong>2</strong> toward A375 and MDA-MB-231 was evaluated using MTT assay and other methods which confirm that both complexes <strong>1</strong> and <strong>2</strong> behave as promising anti-cancer agents.</p></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0020169324004286/pdfft?md5=1f9a22f04d6309fd56c1f13995d7a8d8&pid=1-s2.0-S0020169324004286-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Design and synthesis of two new thiosemicarbazide based Schiff base metal complexes of nickel (II): DNA binding study and cytotoxicity profile analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.ica.2024.122337\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Two new nickel (II) substituted thiosemicarbazone Schiff base complexes [Ni(meph)<sub>2</sub>] (1) [where H<sub>2</sub>meph = (2E)-<em>N</em>-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine-1-carbothioamide] and [Ni(hmm)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O (2) [where H<sub>2</sub>hmm = (2E)-2-[(2-hydroxyphenyl)methylidene]-<em>N</em>-methylhydrazine-1-carbothioamide] have been designed and synthesized by the condensation of 4-methyl-3-thiosemicarbazide with 2-acetylpyridine and salicylaldehyde respectively. Both the metal complexes <strong>1</strong> and <strong>2</strong> are characterized using different available spectroscopic techniques like FT-IR, UV–Vis spectroscopy, elemental analysis, and single crystal X-ray structure analysis. X-ray crystal structure analysis reveal that complex <strong>1</strong> and <strong>2</strong> are octahedral Ni(II) complexes. The calf-thymus CT-DNA-binding property of <strong>1</strong> and <strong>2</strong> has been evaluated by employing UV–Vis and fluorescence spectral titration. All the results show that CT-DNA binds with both nickel(II) complexes <strong>1</strong> and <strong>2</strong>. In vitro cytotoxicity activity of complexes <strong>1</strong> and <strong>2</strong> toward A375 and MDA-MB-231 was evaluated using MTT assay and other methods which confirm that both complexes <strong>1</strong> and <strong>2</strong> behave as promising anti-cancer agents.</p></div>\",\"PeriodicalId\":13599,\"journal\":{\"name\":\"Inorganica Chimica Acta\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0020169324004286/pdfft?md5=1f9a22f04d6309fd56c1f13995d7a8d8&pid=1-s2.0-S0020169324004286-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganica Chimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020169324004286\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020169324004286","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Design and synthesis of two new thiosemicarbazide based Schiff base metal complexes of nickel (II): DNA binding study and cytotoxicity profile analysis
Two new nickel (II) substituted thiosemicarbazone Schiff base complexes [Ni(meph)2] (1) [where H2meph = (2E)-N-methyl-2-[1-(pyridin-2-yl)ethylidene]hydrazine-1-carbothioamide] and [Ni(hmm)2](NO3)2·2H2O (2) [where H2hmm = (2E)-2-[(2-hydroxyphenyl)methylidene]-N-methylhydrazine-1-carbothioamide] have been designed and synthesized by the condensation of 4-methyl-3-thiosemicarbazide with 2-acetylpyridine and salicylaldehyde respectively. Both the metal complexes 1 and 2 are characterized using different available spectroscopic techniques like FT-IR, UV–Vis spectroscopy, elemental analysis, and single crystal X-ray structure analysis. X-ray crystal structure analysis reveal that complex 1 and 2 are octahedral Ni(II) complexes. The calf-thymus CT-DNA-binding property of 1 and 2 has been evaluated by employing UV–Vis and fluorescence spectral titration. All the results show that CT-DNA binds with both nickel(II) complexes 1 and 2. In vitro cytotoxicity activity of complexes 1 and 2 toward A375 and MDA-MB-231 was evaluated using MTT assay and other methods which confirm that both complexes 1 and 2 behave as promising anti-cancer agents.
期刊介绍：
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.
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