外周静脉胀大反射在调节血液动力学中的作用：微型综述

IF 3.2 4区医学 Q2 NEUROSCIENCES Autonomic Neuroscience-Basic & Clinical Pub Date : 2024-09-07 DOI:10.1016/j.autneu.2024.103217

Takuto Hamaoka, Lawrence I. Sinoway, Jian Cui

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引用次数: 0

摘要

人体静脉中汇集了大量的血液，而这些血液会因各种生理压力和疾病而发生显著变化。多项动物和人体研究表明，肢体静脉扩张会引起血压和交感神经活动（静脉扩张反射，VDR）的显著增加。VDR之所以备受关注，是因为它有可能解释多种疾病中自律神经功能失调的未知机制，进而找到新的治疗方法。这篇微型综述讨论了目前积累的有关 VDR 的证据，以及今后应如何研究才能将目前对 VDR 的理解应用于临床实践。

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The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.