A. S. Batova, D. L. Pilinskaya, E. B. Dushanov, E. A. Nasonova, A. N. Bugai
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引用次数: 0
摘要
摘要 这项工作旨在对稀有电离辐射诱导的双链 DNA 断裂的修复过程进行数学模拟。对细胞对辐照反应的几个阶段进行了数学模拟：(i)处于培养生长静止期的中国仓鼠 V79 系细胞对 250 keV X 射线辐照的反应；(ii)处于培养生长指数期的人类癌细胞对 \(γ \)-Co\(^{{60}}\) 辐照的反应。研究了 DNA 双链断裂的诱导和修复以及错误修复的 DNA 双链断裂的形成动力学。模拟数据与实验值进行了比较。
Repair Kinetics of DNA Double-Strand Breaks in Mammalian Cells under Photon Irradiation
Abstract
This work aims at mathematically simulating the repair process of double-strand DNA breaks induced by rare ionizing radiation. A mathematical simulation of several stages of the cellular response to irradiation has been carried out: (i) Chinese hamster cells of the V79 line in the stationary phase of culture growth to the action of 250 keV X-ray irradiation and (ii) human carcinoma cells in the exponential phase of culture growth to \(\gamma \)-Co\(^{{60}}\) irradiation. The induction and repair of DNA double-strand breaks and the kinetics of formation of incorrectly repaired DNA double-strand breaks are studied. The simulation data are compared with experimental values.
期刊介绍：
The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
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