柯里拉京对酒精性肝损伤的保护作用

IF 1.5 4区 医学 Q4 CHEMISTRY, MEDICINAL Natural Product Communications Pub Date : 2024-09-10 DOI:10.1177/1934578x241257089
Xudan Li, Xuan Li, Yuan Deng, Lianghua Chen, Zhizhong Zheng, Yanlin Ming
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引用次数: 0

摘要

目的草药产品柯里拉京因其保护肝脏的功效和抗氧化特性而闻名。然而,柯里拉京在酒精性肝损伤中的保护作用仍有待探索。本研究旨在探讨柯里拉京在 HepG2 细胞和小鼠模型中对酒精性肝损伤的保护作用。用 800 mM 乙醇预处理 HepG2 细胞 24 小时,然后再用柯里拉京处理 24 小时,以评估其护肝活性。在体内研究中,给接受或未接受柯里拉京治疗的 ICR 小鼠注射乙醇 4 周,以诱导酒精性肝损伤。研究结果表明,柯里拉京具有显著的清除自由基的能力,并能减轻酒精诱导的体外细胞损伤。在体内,柯里拉京能显著降低酒精性肝损伤小鼠的肝指数和血清中天门冬氨酸氨基转移酶、丙氨酸转氨酶、总胆固醇和甘油三酯的水平。此外,柯里拉京还能降低肝组织中的 ROS 水平,提高抗氧化酶 CAT、SOD 和 GSH-Px 的活性。结论我们的数据有力地表明,柯里拉京在体外和体内对酒精性肝损伤都具有保护作用,这很可能归功于其卓越的抗氧化能力。总之,柯里拉京有望成为预防或治疗酒精性肝损伤的潜在药物。
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Protective Effect of Corilagin on Alcoholic Liver Injury
ObjectivesThe herbal product corilagin is renowned for its liver-protecting benefits and antioxidant properties. However, the protective role of corilagin in alcoholic liver injury remains unexplored. The objective of this study is to delve into the protective effects of corilagin on alcoholic liver injury, both in HepG2 cells and a mouse model.MethodsTo assess the antioxidant capacity of corilagin in vitro, DPPH and ABTS assays were conducted. HepG2 cells were pretreated with 800 mM ethanol for 24 hours, followed by corilagin treatment for another 24 hours, to evaluate its liver-protecting activity. For in vivo studies, ICR mice, with and without corilagin treatment, were given ethanol for 4 weeks to induce alcoholic liver injury. At the end of the study, serum and liver tissue samples were collected to analyze liver function, enzymatic antioxidants, reactive oxygen species (ROS) levels, alcohol dehydrogenase, and liver tissue histology.ResultsThe findings reveal that corilagin exhibits remarkable free radical scavenging ability and alleviates alcohol-induced cell damage in vitro. In vivo, corilagin significantly reduced liver index and serum levels of aminotransferase aspartate, alanine transaminase, total cholesterol, and triglyceride in mice with alcoholic liver injury. Additionally, corilagin decreased ROS levels in liver tissue and increased the activities of antioxidant enzymes CAT, SOD, and GSH-Px. GSH content increased, while lipid peroxide MDA decreased in liver tissue.ConclusionOur data strongly suggests that corilagin possesses protective effects on alcoholic liver injury, both in vitro and in vivo, which is likely attributed to its exceptional antioxidant capacity. In summary, corilagin holds promise as a potential preventive or therapeutic agent for alcoholic liver injury.
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来源期刊
Natural Product Communications
Natural Product Communications 工程技术-食品科技
CiteScore
3.10
自引率
11.10%
发文量
254
审稿时长
2.7 months
期刊介绍: Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.
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