植物天然产品的抗真菌机制：综述

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL Natural Product Communications Pub Date : 2024-08-31 DOI:10.1177/1934578x241271747

Nanbiao Long, Fang Li

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引用次数: 0

摘要

在过去几十年里，真菌对现有有限的抗真菌剂产生抗药性已成为一个严重的公共卫生问题。然而，具有多种生物活性的天然产物是开发新的真菌治疗药物的重要来源。因此，迫切需要掌握天然产物的抗真菌机制。这篇综述阐述了从植物中提取的天然产物的主要抗真菌机制，包括针对细胞壁、细胞膜、线粒体、生物膜和其他机制。文章批判性地描述了具有高抗真菌活性的化合物，揭示了未来研究的机会，如临床试验或用作环境消毒剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antifungal Mechanism of Natural Products Derived from Plants: A Review

Fungal resistance to the limited existing antifungal agents has become a considerable public health problem in the past few decades. However, natural products with multiple bioactivities are important sources for developing new therapeutic agents against fungi. Consequently, there is an urgent need to grasp the antifungal mechanism of natural products. In this review, the primary antifungal mechanisms of natural products derived from plants, including targeting the cell wall, cell membrane, mitochondria, biofilm and other mechanisms, are elaborated. This article critically describes the compounds with high antifungal activity, revealing opportunities for future research such as clinical trials or utilization as environmental disinfectants.

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来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.