利用磁共振、超声波和组织学图像分析确定电感适度热疗对肿瘤内肉瘤-45异质性的影响特征

Q1 Mathematics Applied Sciences Pub Date : 2024-09-13 DOI:10.3390/app14188251
Valerii B. Orel, Olga Yo. Dasyukevich, Valerii E. Orel, Oleksandr Yu. Rykhalskyi, Larysa M. Kovalevska, Olexander Yu. Galkin, Karyna S. Matveichuk, Anatolii G. Diedkov, Vasyl V. Ostafiichuk, Oleksandr S. Shablii
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引用次数: 0

摘要

通过图像纹理分析评估肿瘤内异质性可以更深入地了解肉瘤对治疗的反应。我们利用磁共振成像(MRI)、超声波和组织学图像分析,研究了诱导性中度热疗(IMH)对肉瘤-45生长的影响,以及在组织、细胞和分子水平上的瘤内异质性。与未经处理的对照组相比,IMH(42 MHz,20 W)可将肉瘤-45的生长动力学抑制34%。T2- 加权核磁共振成像亮度增加了 42%,反映出肿瘤坏死范围更广,而杨氏模量增加了 37%,这是因为在 IMH 作用下结缔组织置换更明显。莫兰空间自相关指数的计算显示,在未接受治疗的肿瘤动物中,核磁共振成像、超声波和组织学检查显示肿瘤核心、外围和囊内感兴趣区(ROI)之间存在异质性差异,而在接受 IMH 治疗后,肿瘤核心和外围之间没有显著差异。暴露于IMH后,核磁共振成像上的整体肿瘤ROI异质性增加了22%,但超声波和组织学图像上的核心和外围异质性却降低了。IMH后,Ki-67蛋白分布在肿瘤周边的异质性降低了25%。因此,本研究利用实验成像数据定量分析了 IMH 对肿瘤内肉瘤-45 不同表现异质性的影响。
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Characterization of Inductive Moderate Hyperthermia Effects on Intratumor Sarcoma-45 Heterogeneity Using Magnetic Resonance, Ultrasound and Histology Image Analysis
Evaluating intratumor heterogeneity with image texture analysis offers a more sophisticated understanding of sarcoma response to treatment. We examined the effects of inductive moderate hyperthermia (IMH) on sarcoma-45 growth and intratumor heterogeneity across tissue, cellular and molecular levels using magnetic resonance imaging (MRI), ultrasound and histology image analysis. IMH (42 MHz, 20 W) inhibited sarcoma-45 growth kinetics by 34% compared to the untreated control group. T2-weighted MRI brightness was increased by 42%, reflecting more extensive tumor necrosis, while Young’s modulus increased by 37% due to more pronounced connective tissue replacement in response to IMH. Whereas calculations of Moran’s spatial autocorrelation index revealed distinctions in heterogeneity between tumor core, periphery and capsule regions of interest (ROIs) on MRI, ultrasound and histological examination in the untreated tumor-bearing animals, there was no significant difference between core and periphery after IMH. Exposure to IMH increased overall tumor ROI heterogeneity by 22% on MRI but reduced heterogeneity in the core and periphery on ultrasound and histology images. Ki-67 protein distribution was 25% less heterogeneous on the tumor periphery after IMH. Therefore, this study provides a quantitative characterization of IMH effects on different manifestations of intratumor sarcoma-45 heterogeneity using experimental imaging data.
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来源期刊
Applied Sciences
Applied Sciences Mathematics-Applied Mathematics
CiteScore
6.40
自引率
0.00%
发文量
0
审稿时长
11 weeks
期刊介绍: APPS is an international journal. APPS covers a wide spectrum of pure and applied mathematics in science and technology, promoting especially papers presented at Carpato-Balkan meetings. The Editorial Board of APPS takes a very active role in selecting and refereeing papers, ensuring the best quality of contemporary mathematics and its applications. APPS is abstracted in Zentralblatt für Mathematik. The APPS journal uses Double blind peer review.
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