肯尼亚复发性外阴阴道念珠菌病患者群体的血浆炎症蛋白质组概况

IF 4.2 2区 生物学 Q2 MICROBIOLOGY Journal of Fungi Pub Date : 2024-09-06 DOI:10.3390/jof10090638
Diletta Rosati, Isis Ricaño Ponce, Gloria S. Omosa-Manyonyi, Mariolina Bruno, Nelly W. Kamau, Martin Jaeger, Vinod Kumar, Mihai G. Netea, Andre J. A. M. van der Ven, Jaap ten Oever
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引用次数: 0

摘要

多达 75% 的妇女一生中至少患过一次外阴阴道念珠菌病(VVC),多达 8% 的妇女经常反复发作外阴阴道念珠菌病(RVVC)。缺乏宿主保护性反应是阴道念珠菌感染的基础,而失调的高炎症反应则可能导致 RVVC。考虑到使用激素避孕药对全身炎症的潜在影响,本研究旨在调查非洲人群中患有 RVVC 的妇女的全身炎症蛋白谱。我们使用多重临近扩展分析技术,测量了 158 名 RVVC 患者和 92 名无症状女性(对照组)血浆样本中的 92 种循环系统炎症蛋白。在 RVVC 患者和无症状女性中,使用荷尔蒙避孕药与全身炎症蛋白谱均无统计学意义上的显著相关性。与健康对照组相比,RVVC 妇女的循环成纤维细胞生长因子 21 (FGF-21) 浓度较低(调整后 p 值 = 0.028)。FGF-21浓度的降低可能与通过IL-1β在RVVC病例中观察到的免疫病理学有关。这项研究可能有助于确定新的生物标志物,用于诊断和未来开发新型免疫调节疗法治疗 RVVC。
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Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya
Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, and up to 8% of women suffer from frequent recurrent episodes of VVC (RVVC). A lack of a protective host response underlies vaginal Candida infections, while a dysregulated hyperinflammatory response may drive RVVC. This study aimed to investigate the systemic inflammatory protein profile in women with RVVC in an African population, considering the potential influence of hormonal contraceptive use on systemic inflammation. Using multiplex Proximity Extension Assay technology, we measured 92 circulatory inflammatory proteins in plasma samples from 158 RVVC patients and 92 asymptomatic women (controls). Hormonal contraceptive use was not found to have a statistically significant correlation with a systemic inflammatory protein profile in either RVVC patients or the asymptomatic women. RVVC women had lower circulating Fibroblast Growth Factor 21 (FGF-21) concentrations compared with healthy controls (adjusted p value = 0.028). Reduced concentrations of FGF-21 may be linked to the immune pathology observed in RVVC cases through IL-1β. This study may help to identify new biomarkers for the diagnosis and future development of novel immunomodulatory treatments for RVVC.
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来源期刊
Journal of Fungi
Journal of Fungi Medicine-Microbiology (medical)
CiteScore
6.70
自引率
14.90%
发文量
1151
审稿时长
11 weeks
期刊介绍: Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.
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