妊娠期肾脏的线粒体功能和抗氧化能力

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI:10.1007/s10517-024-06205-w

V. A. Popkov, M. I. Buyan, K. I. Makievskaya, A. A. Brezgunova, I. B. Pevzner, L. D. Zorova, D. B. Zorov, E. Yu. Plotnikov, N. V. Andrianova

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引用次数: 0

摘要

我们证实，怀孕大鼠的血清能提高肾脏上皮细胞的活力并促进其增殖。怀孕期间肾脏氧化应激的强度也有所降低，但仅限于未受到急性缺血性肾损伤的大鼠。氧化应激的降低与线粒体跨膜电位、线粒体大小、线粒体通透性转换孔（mPTP）开放时间、线粒体呼吸速率、抗氧化活性或一氧化氮水平的变化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy

We demonstrated that the serum of pregnant rats increases viability of kidney epithelial cells and promotes their proliferation. The intensity of oxidative stress in the kidneys was also reduced during pregnancy, but only in rats that were not exposed to acute ischemic kidney injury. This decrease in oxidative stress was not associated with changes in transmembrane mitochondrial potential, the size of mitochondria, time of opening of mitochondrial permeability transition pore (mPTP), mitochondrial respiration rate, antioxidant activity, or nitric oxide level.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.