结核病诊断和治疗中与临床相关的金属纳米粒子

IF 3.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY Advanced Therapeutics Pub Date : 2024-08-21 DOI:10.1002/adtp.202400189
Christianah Aarinola Akinnawo, Admire Dube
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引用次数: 0

摘要

全球面临着结核病(TB)的沉重负担,由于患者不坚持治疗以及耐药菌株以惊人的速度蔓延,结核病很难根除。需要采用新方法来改进诊断和治疗。金属纳米粒子(MNPs)已证明具有作为传感器探针和联合疗法的潜力,这种疗法将 MNPs 与抗霉菌药物相结合,以开发新的治疗和治疗方法。为了加强结核病纳米药物临床应用的理论基础,本综述重点介绍了与治疗相关的 MNPs 的特性和有效性。本综述还阐述了它们的抗结核机制。本综述旨在分析有关该主题的大量文献,指出重要的经验性发现,并找出知识差距,为今后的研究工作和技术转化奠定基础。目前的数据表明,MNPs 是一种潜在的高效诊断和治疗系统,但要将这些技术应用于临床,还需要进行更多的临床前和临床研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy
Globally a significant burden of tuberculosis (TB) is faced, which is difficult to eradicate due to patients' non‐adherence, and drug‐resistant strains that are spreading at an alarming rate. Novel approaches are required to improve diagnosis and treatment. Metallic nanoparticles (MNPs) have demonstrated potential as sensor probes and in combination therapy, which combines MNPs with antimycobacterial drugs to develop new treatment and theranostic approaches. To strengthen the theoretical foundation toward the clinical application of TB nanomedicine, this review focuses on the properties and effectiveness of therapeutically relevant MNPs. It also elaborates on their antimycobacterial mechanisms. This review aims to analyze the body of literature on the topic, pinpoint important empirical findings, and identify knowledge gaps that can provide a basis for future research endeavors and translation of the technologies. Current data suggest that MNPs are potential systems for efficient diagnosis and treatment although additional pre‐clinical and clinical research is needed to bring these technologies to the clinic.
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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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