Gemma Webb, Mei Yen Michelle Leong, Emma Bishop, Marjoree Sehu
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Diagnostic Dilemmas: A Review of Reported Cases of Human Herpesvirus-6 Encephalitis in Immunocompetent Adults
Human Herpesvirus 6 (HHV-6) is associated with its presentation in the paediatric population as roseola infantum. Rarely, it is the causative agent of encephalitis, with most cases reported amongst the immunocompromised population due to reactivation. This review article analyses the available literature records of cases labelled as HHV-6 encephalitis in immunocompetent adults, aiming to understand the diagnostic methods behind each case and explore the complexities of such a diagnosis. We note significant variability in the methods used to come to a diagnosis of HHV-6 encephalitis, as well as inconsistent approaches to treatment of this condition. Given the rarity of HHV-6 encephalitis in immunocompetent adults, there are no clearly structured diagnostic guidelines for this condition in this patient population. We highlight several diagnostic methods that provide more convincing evidence of true HHV-6 encephalitis and may provide a basis for further development of guidelines for the diagnosis and treatment of this condition.
期刊介绍:
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.