Gustavo Amorim, David W. Haas, Marcelo Cordeiro-Santos, Afrânio L. Kritski, Marina C. Figueiredo, Cody Staats, Brian Hachey, Megan Turner, Bruno B. Andrade, Valeria C. Rolla, Timothy R. Sterling, the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil network
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Estimating optimal therapeutic drug levels of anti-tuberculosis medications based on treatment safety and effectiveness
Background Therapeutic drug ranges (TDR) for standard anti-tuberculosis (TB) treatment have been determined based on expected drug levels at least 2 hours after taking the dose. In this study we constructed TDR for TB drug levels based on minimizing drug toxicity and maximizing treatment effectiveness.
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