慢性铍接触对肝肺功能和血液学参数的影响

IF 2.5 4区 地球科学 Q3 ENVIRONMENTAL SCIENCES Atmosphere Pub Date : 2024-09-07 DOI:10.3390/atmos15091086
Jing Dai, Xinlin Bi, Hui Yuan, Qingyu Meng, Yina Yang, Xueqin Wang, Xiaoying Ma, Chunguang Ding, Fen Wang
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引用次数: 0

摘要

铍是一种对人体有毒的轻金属。与铍接触有关的主要健康影响是肝脏毒性、免疫系统毒性和慢性铍病(CBD)。本研究调查了职业铍暴露对铍冶炼工人肝、肺功能和血液学参数的影响。这项横断面研究比较了 65 名接触铍的工人和 34 名未接触铍的工人。通过问卷调查和生化测试收集了健康信息。采用电感耦合等离子体质谱法(ICP-MS)测定了尿铍的浓度。结果显示,接触铍的工人和对照组的尿铍水平分别为 0.48 (0.115, 1.19) μg/mL 和 0.0125 (0.005, 0.005) μg/mL (p < 0.001)。与对照组相比,暴露工人的血清丙氨酸氨基转移酶(ALT)水平、血红蛋白(HGB)浓度、白细胞(WBC)计数、红细胞(RBC)计数以及收缩压和舒张压(SBP、DBP)均显著升高(p < 0.05)。此外,血红蛋白(HGB)浓度和谷丙转氨酶(ALT)水平与尿液中的铍浓度有明显相关性(p < 0.05)。与对照组相比,暴露工人尿液中的铍浓度有所增加。此外,接触铍的工人尿液中的铍含量远高于中国普通人群。接触铍的工人可能有肝脏和血液系统受损的风险。
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Impact of Chronic Beryllium Exposure on Liver and Lung Function and Hematologic Parameters
Beryllium is a lightweight metal that is toxic to humans. The critical health effects related to beryllium exposure are liver toxicity, immune system toxicity, and chronic beryllium disease (CBD). This study investigated the effects of occupational beryllium exposure on liver and lung function and hematologic parameters among beryllium smelter workers. A cross-sectional study was performed by comparing 65 exposed workers and 34 non-exposed workers. Health information was collected through questionnaire surveys and biochemical tests. The concentration of urinary beryllium was determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The findings indicated that the urinary beryllium levels of the exposed workers and the controls were 0.48 (0.115, 1.19) μg/mL and 0.0125 (0.005, 0.005) μg/mL, respectively (p < 0.001). Compared with the controls, the exposed workers showed a significant increase in serum alanine aminotransferase (ALT) level, hemoglobin (HGB) concentration, white blood cell (WBC) count, red blood cell (RBC) count, and systolic and diastolic blood pressure (SBP, DBP) (p < 0.05). Furthermore, the HGB concentration and ALT level were significantly correlated with the concentration of beryllium in urine (p < 0.05). The exposed workers had increased urinary concentrations of beryllium, in contrast to the control subjects. Moreover, the urinary beryllium levels among the exposed workers are much higher than that in the Chinese general population. Beryllium-exposed workers may be at risk of liver and hematologic impairments.
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来源期刊
Atmosphere
Atmosphere METEOROLOGY & ATMOSPHERIC SCIENCES-
CiteScore
4.60
自引率
13.80%
发文量
1769
审稿时长
1 months
期刊介绍: Atmosphere (ISSN 2073-4433) is an international and cross-disciplinary scholarly journal of scientific studies related to the atmosphere. It publishes reviews, regular research papers, communications and short notes, and there is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.
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