Sara A. Norton, Aaron J. Gorelik, Sarah E. Paul, Emma C. Johnson, David AA Baranger, Jayne L Siudzinski, Zhaolong Adrian Li, Erin Bondy, Hailey Modi, Nicole R. Karcher, Tamara Hershey, Alexander S. Hatoum, Arpana Agrawal, Ryan Bogdan
{"title":"欧洲血统儿童 C-Reactive 蛋白遗传风险全表型关联研究 (PheWAS)：ABCD 研究的结果","authors":"Sara A. Norton, Aaron J. Gorelik, Sarah E. Paul, Emma C. Johnson, David AA Baranger, Jayne L Siudzinski, Zhaolong Adrian Li, Erin Bondy, Hailey Modi, Nicole R. Karcher, Tamara Hershey, Alexander S. Hatoum, Arpana Agrawal, Ryan Bogdan","doi":"10.1101/2024.08.30.24312857","DOIUrl":null,"url":null,"abstract":"<strong>BACKGROUND</strong> C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in childhood may inform our understanding of variability in CRP that could be targeted to prevent and/or delay the onset of related health outcomes.","PeriodicalId":501375,"journal":{"name":"medRxiv - Genetic and Genomic Medicine","volume":"37 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study\",\"authors\":\"Sara A. Norton, Aaron J. Gorelik, Sarah E. Paul, Emma C. Johnson, David AA Baranger, Jayne L Siudzinski, Zhaolong Adrian Li, Erin Bondy, Hailey Modi, Nicole R. Karcher, Tamara Hershey, Alexander S. Hatoum, Arpana Agrawal, Ryan Bogdan\",\"doi\":\"10.1101/2024.08.30.24312857\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>BACKGROUND</strong> C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in childhood may inform our understanding of variability in CRP that could be targeted to prevent and/or delay the onset of related health outcomes.\",\"PeriodicalId\":501375,\"journal\":{\"name\":\"medRxiv - Genetic and Genomic Medicine\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Genetic and Genomic Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.08.30.24312857\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Genetic and Genomic Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.30.24312857","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study
BACKGROUND C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in childhood may inform our understanding of variability in CRP that could be targeted to prevent and/or delay the onset of related health outcomes.
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