Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer
{"title":"细胞外 HSPB1 促成酒精相关性肝炎炎症的证据","authors":"Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer","doi":"10.1101/2024.09.06.24313193","DOIUrl":null,"url":null,"abstract":"<strong>Background and aims</strong> Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.","PeriodicalId":501258,"journal":{"name":"medRxiv - Gastroenterology","volume":"75 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis\",\"authors\":\"Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer\",\"doi\":\"10.1101/2024.09.06.24313193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background and aims</strong> Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.\",\"PeriodicalId\":501258,\"journal\":{\"name\":\"medRxiv - Gastroenterology\",\"volume\":\"75 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Gastroenterology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.06.24313193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.06.24313193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis
Background and aims Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.
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