{"title":"ALI/ARDS 的新治疗靶点：叉头盒转录因子","authors":"Xi Zhu, Leyuan Meng, Liqin Xu, Yun Hua, Jian Feng","doi":"10.1007/s00408-024-00740-z","DOIUrl":null,"url":null,"abstract":"<p>ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body’s normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body’s immune response through different signalling pathways. Forkhead box transcription factors are evolutionarily conserved transcription factors that play a crucial role in various cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Transcription factors control protein synthesis by regulating gene transcription levels, resulting in diverse biological outcomes. The Fox family plays a role in activating or inhibiting the expression of various molecules related to ALI/ARDS through phosphorylation, acetylation/deacetylation, and control of multiple signalling pathways. An in-depth analysis of the integrated Fox family’s role in ALI/ARDS can aid in the development of potential diagnostic and therapeutic targets for the condition.</p>","PeriodicalId":18163,"journal":{"name":"Lung","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors\",\"authors\":\"Xi Zhu, Leyuan Meng, Liqin Xu, Yun Hua, Jian Feng\",\"doi\":\"10.1007/s00408-024-00740-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body’s normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body’s immune response through different signalling pathways. Forkhead box transcription factors are evolutionarily conserved transcription factors that play a crucial role in various cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Transcription factors control protein synthesis by regulating gene transcription levels, resulting in diverse biological outcomes. The Fox family plays a role in activating or inhibiting the expression of various molecules related to ALI/ARDS through phosphorylation, acetylation/deacetylation, and control of multiple signalling pathways. An in-depth analysis of the integrated Fox family’s role in ALI/ARDS can aid in the development of potential diagnostic and therapeutic targets for the condition.</p>\",\"PeriodicalId\":18163,\"journal\":{\"name\":\"Lung\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lung\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00408-024-00740-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00408-024-00740-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
摘要
ALI/ARDS 可能是全身炎症反应的肺部表现，也可能是机体正常炎症反应过度表达的结果，其中涉及各种效应细胞、细胞因子和炎症介质，它们通过不同的信号通路调节机体的免疫反应。叉头盒转录因子是进化保守的转录因子，在细胞周期进展、增殖、分化、迁移、新陈代谢和 DNA 损伤反应等各种细胞过程中发挥着至关重要的作用。转录因子通过调节基因转录水平来控制蛋白质的合成，从而产生不同的生物学结果。Fox 家族通过磷酸化、乙酰化/去乙酰化和控制多种信号通路，在激活或抑制与 ALI/ARDS 相关的各种分子的表达方面发挥作用。深入分析 Fox 家族在 ALI/ARDS 中的综合作用有助于开发该病的潜在诊断和治疗靶点。
Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors
ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body’s normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body’s immune response through different signalling pathways. Forkhead box transcription factors are evolutionarily conserved transcription factors that play a crucial role in various cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Transcription factors control protein synthesis by regulating gene transcription levels, resulting in diverse biological outcomes. The Fox family plays a role in activating or inhibiting the expression of various molecules related to ALI/ARDS through phosphorylation, acetylation/deacetylation, and control of multiple signalling pathways. An in-depth analysis of the integrated Fox family’s role in ALI/ARDS can aid in the development of potential diagnostic and therapeutic targets for the condition.
期刊介绍：
Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
