废物衍生的钙锌双金属(钙/锌)纳米棒包裹壳聚糖止血敷料绷带:向废物变绷带迈出的一步

IF 5.9 3区 工程技术 Q1 CHEMISTRY, MULTIDISCIPLINARY Journal of Industrial and Engineering Chemistry Pub Date : 2024-08-23 DOI:10.1016/j.jiec.2024.08.035
Pooja Thakur, Rishabh Anand Omar, Neetu Talreja, Divya Chauhan, Mohammad Ashfaq
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引用次数: 0

摘要

在军事战争、外伤和外科手术中控制失血是当今最大的挑战,失血会导致死亡,因此需要止血绷带。本研究的重点是利用壳聚糖聚合物(CZC)合成含有 Zn 纳米棒的废物衍生 (WD)-Ca 纳米棒,以控制失血和细菌感染。对制备的 CZC 绷带进行了各种生化测试,如 PBS 吸收、溶血、蛋白质吸附、血小板聚集/粘附、凝血能力和抗菌测试。数据表明,CZC 绷带具有较高的生物相容性、优异的 PBS 吸收能力(∼1402%)、暴露 10 分钟内的血小板聚集能力(∼65%)、蛋白质吸附能力(∼37 mg/cm)和暴露 1 分钟内的凝血能力(∼84%)。此外,CZC 绷带还能有效杀灭/抑制细菌。因此,本研究制备的 CZC 绷带具有简单、经济和可持续发展的特点。
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Waste-derived Ca and Zn-based bimetallic (Ca/Zn) nanorods encapsulated chitosan-based haemostatic dressing bandage: A step towards waste to bandages
Controlling loss of blood during militant war, traumatic injury, and surgical procedures is the greatest challenge nowadays, which leads to death, thereby the necessity of hemostatic bandages. The present work focuses on the synthesis of waste-derived (WD)-Ca incorporated Zn nanorods encapsulated with chitosan polymers (CZC) to control the loss of blood as well as bacterial infection. The as-prepared CZC bandage was tested against various biochemical tests such as PBS absorption, hemolysis, adsorption of protein, platelets aggregation/adhesion, blood clotting ability, and antibacterial test assay. The data suggested that the CZC bandage has high biocompatibility, exceptional PBS absorption ability (∼1402%), platelets aggregation (∼65%) within 10 min of exposure, protein a loading ability (∼37 mg/cm), and ∼84% blood clotting within a 1 min of exposure. Moreover, the CZC bandage effectively kills/inhibits both and bacteria. Therefore, the prepared CZC bandage in this study is simple, economically viable, and sustainable development.
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来源期刊
CiteScore
10.40
自引率
6.60%
发文量
639
审稿时长
29 days
期刊介绍: Journal of Industrial and Engineering Chemistry is published monthly in English by the Korean Society of Industrial and Engineering Chemistry. JIEC brings together multidisciplinary interests in one journal and is to disseminate information on all aspects of research and development in industrial and engineering chemistry. Contributions in the form of research articles, short communications, notes and reviews are considered for publication. The editors welcome original contributions that have not been and are not to be published elsewhere. Instruction to authors and a manuscript submissions form are printed at the end of each issue. Bulk reprints of individual articles can be ordered. This publication is partially supported by Korea Research Foundation and the Korean Federation of Science and Technology Societies.
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