Expanding the Scope of Metal-Free Catalytic Approach for the Green One-Pot Multicomponent Synthesis of β-Amido Carbonyl Scaffolds

An efficient, mild, and green one-pot multicomponent synthetic approach has been proposed for the synthesis of β-amido carbonyl scaffolds via coupling of aromatic aldehydes, enolizable ketones, and acetonitrile in the presence of acetyl chloride and ammonium chloride as a metal-free highly effective catalyst. The developed approach provides a novel cost-effective and environmentally friendly route to access highly functionalized structural scaffolds in in good to excellent yields and requires less operational skill and conditions.