白细胞介素-1 家族细胞因子和化脓性扁桃体炎中的可溶性受体

IF 3.5 3区 医学 Q1 DERMATOLOGY Experimental Dermatology Pub Date : 2024-09-15 DOI:10.1111/exd.15179
Flavia Manzo Margiotta, Gaetana Gambino, Federico Pratesi, Alessandra Michelucci, Francesco Pisani, Leonardo Rossi, Valentina Dini, Marco Romanelli, Paola Migliorini
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引用次数: 0

摘要

化脓性扁平湿疹(HS)是一种慢性皮肤病,其临床特征是毛囊发炎并复发脓肿、结节和隧道。最近有几项研究表明,IL-1 家族(IL-1F)细胞因子在诱发和维持该病方面起着重要作用。这项研究旨在对未接受生物制剂治疗的一组 HS 患者的 IL-1F 细胞因子、可溶性抑制剂和受体进行全面分析。研究人员招募了 16 名 HS 患者和 16 名健康对照者,收集了他们的临床数据,并通过国际 HS 严重程度评分系统(IHS4)评估了疾病的严重程度。血清中 IL-1F 细胞因子、抑制剂和受体的水平采用多重检测法进行测定。患者的 IL-18 和游离 IL-18 水平明显高于对照组。在可溶性抑制剂中,IL-1Ra、IL-1R2 和 ST2/IL-1R4 明显升高。IL-18、游离IL-18和IL-33水平与IHS4密切相关。此外,抑制剂 IL-1Ra 和 IL-18BP 也与 IHS4 相关。本研究获得的数据证实,IL-1F 细胞因子参与了疾病的介导并决定了疾病的严重程度,同时也表明,IL-18 有可能成为活动性疾病的新型血清生物标记物。
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Interleukin-1 family cytokines and soluble receptors in hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic skin disease, characterized by clinical inflammation of the hair follicle with the recurrence of abscesses, nodules, and tunnels. Recently, several studies suggested a role of IL-1 family (IL-1F) cytokines in eliciting and sustaining the disease. The aim of this work is to perform a comprehensive analysis of IL-1F cytokines, soluble inhibitors and receptors in a cohort of HS patients not treated with biological agents. Sixteen patients affected by HS and 16 healthy controls were recruited; clinical data were collected and disease severity evaluated by means of the International HS Severity Score System (IHS4). Serum levels of IL-1F cytokines, inhibitors and receptors were measured using a Multiplex Assays. IL-18 and free IL-18 levels were significantly higher in patients vs controls. Among soluble inhibitors, IL-1Ra, IL-1R2 and ST2/IL-1R4 were significantly increased. IL-18, free IL-18 and IL-33 levels are strongly correlated with IHS4. Also the inhibitors IL-1Ra and IL-18BP show a correlation with IHS4. The data obtained in this study confirm the involvement of IL-1F cytokines in mediating the disease and determining its severity and suggest a possible role for IL-18 as novel serum biomarker of active disease.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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