精氨酰甘氨酰天冬氨酸工程噬菌体纳米纤维在小鼠模型中的体内安全性评估和追踪研究

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Journal of Materials Chemistry B Pub Date : 2024-09-16 DOI:10.1039/d4tb00823e

Kshitiz Raj Shrestha, Sehoon Kim, Anna Jo, Murali Ragothaman, So Young Yoo

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摘要

工程噬菌体 YSY184 模仿细胞外基质纳米纤维，能有效促进干细胞分化和血管生成。本研究在小鼠模型中对其安全性进行了评估，监测了体重、免疫原性、脾脏免疫反应和巨噬细胞浸润。研究观察到 YSY184 被快速清除，3 小时内达到组织存在的峰值，24 小时后显著减少，一个月后可忽略不计。用药后未发现任何不良的生理或病理影响，这肯定了 YSY184 的安全性，并强调了它的治疗潜力，值得进一步临床探索。

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In vivo safety evaluation and tracing of arginylglycylaspartic acid-engineered phage nanofiber in murine model

The engineered phage YSY184, mimicking the extracellular matrix nanofiber, effectively promotes stem cell differentiation and angiogenesis. This study evaluated its safety in a mouse model, monitoring weight, immunogenicity, spleen immune responses, and macrophage infiltration. Rapid clearance of YSY184 was observed, with peak tissue presence within three hours, significantly reduced by 24 hours, and negligible after one month. No adverse physiological or pathological effects were detected post-administration, affirming YSY184's safety and underscore its potential for therapeutic use, warranting further clinical exploration.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices

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