用于诊断慢性肾病的床旁生物传感器和设备

IF 3.5 Q2 CHEMISTRY, ANALYTICAL Sensors & diagnostics Pub Date : 2024-09-16 DOI:10.1039/D4SD00241E
Yuan Liu, Xinping Zhao, Min Liao, Guoliang Ke and Xiao-Bing Zhang
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引用次数: 0

摘要

慢性肾脏病(CKD)是一个日益严重的全球性健康问题,需要早期准确的诊断工具来控制和缓解病情发展。床旁 (POC) 生物传感器和设备为快速、经济、方便的诊断提供了一种前景广阔的解决方案。本综述探讨了专为慢性肾功能衰竭诊断设计的 POC 生物传感器和设备的最新进展。在这篇综述中,我们讨论了最有可能实现 CKD 现场检测的生物传感器,重点是它们在真实样本中的设计和应用,包括电化学、荧光和比色传感器。此外,还总结了横向流动装置、片上实验室装置和微流控装置等创新平台。这些技术在实时监测、早期检测和个性化治疗方面的潜力得到了强调。综述最后展望了 POC 生物传感器在 CKD 诊断中的未来前景和变革性影响,旨在改善患者预后和提高医疗效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Point-of-care biosensors and devices for diagnostics of chronic kidney disease

Chronic kidney disease (CKD) is a growing global health concern, necessitating early and accurate diagnostic tools to manage and mitigate its progression. Point-of-care (POC) biosensors and devices offer a promising solution for rapid, cost-effective, and accessible diagnostics. This review explores the latest advancements in POC biosensors and devices specifically designed for CKD diagnostics. In this review, we discuss the biosensors most likely to achieve on-site detection of CKD, focusing on their design and application in real samples, including electrochemical, fluorescent, and colorimetric sensors. Also, the innovative platforms are summarized from lateral flow devices, lab-on-a-chip devices, and microfluidic-based devices. The potential of these technologies for real-time monitoring, early detection, and personalized treatment is underscored. The review concludes by envisioning future perspectives and the transformative impact of POC biosensors in CKD diagnostics, aiming to improve patient outcomes and healthcare efficiency.

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Back cover Pursuing theranostics: a multimodal architecture approach. A review on Ti3C2Tx based nanocomposites for the electrochemical sensing of clinically relevant biomarkers Back cover Introduction to Supramolecular Sensors: From Molecules to Materials
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