评估接受心脏毒性化疗药物治疗患者的左心房机电延迟和左心房相位功能

Q4 Medicine Medicina Pub Date : 2024-09-18 DOI:10.3390/medicina60091516
Ömer Kertmen, Murat Akcay
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引用次数: 0

摘要

背景:本研究旨在通过比较接受心脏毒性化疗药物治疗的患者化疗前后左心房机械和机电参数来评估心房受累情况。研究方法我们设计了一项前瞻性队列研究。研究对象包括 68 名年龄在 18 至 50 岁之间、计划接受心脏毒性化疗药物治疗的女性患者。研究人员检查了化疗前后的心房机械功能和机电参数,并与基本超声心动图参数进行了比较。研究结果患者的平均年龄为(41.6 ± 7.9)岁。化疗后,侧PA、室间隔PA和三尖瓣PA持续时间显著增加(P<0.001),但左房内机电延迟、右房内机电延迟和房间机电延迟值的变化无统计学意义。治疗后,LAVmax、LAVmin 和 LApreA 显著增加(p < 0.001)。此外,左心房被动和主动排空容量增加(p < 0.001),而储库和泵(主动排空)功能下降(p 值分别为 0.03 和 0.01)。而被动排空功能则无明显变化(p = 0.65)。观察到 LVEF 下降,而 LVEDD、LVESD、IVS、PW 和 LA 直径增加(IVS 的 p 值为 0.02,其他值均小于 0.001)。结论接受心脏毒性化疗药物治疗后,可观察到心房机械功能和机电参数明显受损。这表明使用心脏毒性化疗药物会增加心房心律失常的可能性。
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Evaluation of Left Atrial Electromechanical Delay and Left Atrial Phasic Functions in Patients Undergoing Treatment with Cardiotoxic Chemotherapeutic Agents
Background: The aim of this study is to evaluate atrial involvement by comparing pre- and post-chemotherapy left atrial mechanical and electromechanical parameters in patients treated with cardiotoxic chemotherapeutic agents. Methods: We designed our study as a prospective cohort study. Sixty-eight female patients between the ages of 18 and 50, scheduled for treatment with cardiotoxic chemotherapeutic agents, were included in our study. Atrial mechanical functions and electromechanical parameters were examined and compared with basic echocardiographic parameters before and after chemotherapy. Results: The mean age of the patients was 41.6 ± 7.9 years. After chemotherapy, lateral PA, septal PA, and tricuspid PA durations showed a significant increase (p < 0.001), but there were no statistically significant changes in the left intra-atrial electromechanical delay, the right intra-atrial electromechanical delay, or the interatrial electromechanical delay values. Following treatment, LAVmax, LAVmin, and LApreA significantly increased (p < 0.001). Additionally, the left atrial passive and active emptying volumes increased (p < 0.001), while the reservoir and pump (active emptying) functions decreased (with p-values of 0.03 and 0.01, respectively). The passive emptying function, however, showed no significant change (p = 0.65). Decreases in LVEF were observed, while LVEDD, LVESD, IVS, PW, and LA diameters increased (p-value of 0.02 for IVS and <0.001 for the others). Conclusions: Significant impairment of atrial mechanical functions and electromechanical parameters was observed after treatment with cardiotoxic chemotherapeutic agents. This suggests an elevated likelihood of atrial arrhythmia linked to the use of cardiotoxic chemotherapeutic agents.
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来源期刊
Medicina
Medicina Medicine-Medicine (all)
CiteScore
0.10
自引率
0.00%
发文量
66
审稿时长
24 weeks
期刊介绍: Publicada con el apoyo del Ministerio de Ciencia, Tecnología e Innovación Productiva. Medicina no tiene propósitos comerciales. El objeto de su creación ha sido propender al adelanto de la medicina argentina. Los beneficios que pudieran obtenerse serán aplicados exclusivamente a ese fin.
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