心血管代谢性高血压(HFpEF)的生活方式干预:饮食和运动方式

IF 4.5 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Heart Failure Reviews Pub Date : 2024-09-16 DOI:10.1007/s10741-024-10439-1
Antonio Vacca, Rongling Wang, Natasha Nambiar, Federico Capone, Catherine Farrelly, Ahmed Mostafa, Leonardo A. Sechi, Gabriele G. Schiattarella
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引用次数: 0

摘要

射血分数保留型心力衰竭(HFpEF)正迅速发展成为最常见的心力衰竭形式。在射血分数保留型心力衰竭表型中,心脏代谢/肥胖型射血分数保留型心力衰竭(HFpEF)--由心脏代谢改变引起的射血分数保留型心力衰竭--是该综合征最常见的形式之一,也是最近治疗取得成功的一种。事实上,使用钠-葡萄糖共转运体 2 型抑制剂(SGLT2i)和胰高血糖素样肽-1 受体激动剂(GLP-1RA)的药物治疗方法因其代谢保护作用而被证明是有效的。同样,生活方式的改变,包括饮食和运动,在高频血栓栓塞治疗中也至关重要。越来越多的证据表明,饮食和体育锻炼在 HFpEF 的发病机制、预后和潜在逆转中发挥着重要作用。代谢紊乱和全身炎症是 HFpEF 的主要特征,也是生活方式干预的主要目标。然而,这些干预措施对 HFpEF 产生有益影响的内在机制尚未完全明了。因此,为 HFpEF 患者量身定制生活方式干预方法的需求尚未得到满足。在此,我们将介绍目前生活方式干预在高频心衰管理和治疗中的可用证据,并讨论其模式和潜在机制。
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Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities

Heart failure with preserved ejection fraction (HFpEF) is rapidly growing as the most common form of heart failure. Among HFpEF phenotypes, the cardiometabolic/obese HFpEF — HFpEF driven by cardiometabolic alterations — emerges as one of the most prevalent forms of this syndrome and the one on which recent therapeutic success have been made. Indeed, pharmacological approaches with sodium-glucose cotransporter type 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have proved to be effective due to metabolic protective effects. Similarly, lifestyle changes, including diet and exercise are crucial in HFpEF management. Increasing evidence supports the important role of diet and physical activity in the pathogenesis, prognosis, and potential reversal of HFpEF. Metabolic derangements and systemic inflammation are key features of HFpEF and represent the main targets of lifestyle interventions. However, the underlying mechanisms of the beneficial effects of these interventions in HFpEF are incompletely understood. Hence, there is an unmet need of tailored lifestyle intervention modalities for patients with HFpEF. Here we present the current available evidence on lifestyle interventions in HFpEF management and therapeutics, discussing their modalities and potential mechanisms.

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来源期刊
Heart Failure Reviews
Heart Failure Reviews 医学-心血管系统
CiteScore
10.40
自引率
2.20%
发文量
90
审稿时长
6-12 weeks
期刊介绍: Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.
期刊最新文献
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