{"title":"使用支撑金纳米颗粒和酰基辅酶 A 连接酶混合合成 AMFC 衍生酰胺","authors":"Lucas, Bisel, Aurélie, Fossey-Jouenne, Richard, Martin, Jonathan, Bassut, Antoine, Lancien, Louis, Mouterde, Vivien, Herrscher, Muriel, Billamboz, Carine, Vergne-Vaxelaire, Rénato, Froidevaux, Anne, Zaparucha, Egon, Heuson","doi":"10.26434/chemrxiv-2024-2d7wr","DOIUrl":null,"url":null,"abstract":"By integrating different types of catalysts in the same system, hybrid catalysis emerges as an attractive and competitive approach. Within the framework of valorizing sustainably sourced bio-based products, we herein present a synthetic method for producing amides from alcohols and the bio-sourced 5-aminomethyl-2-furancarboxylic acid (AMFC). This approach utilizes supported gold metal nanoparticles as heterogeneous chemocatalysts, in conjunction with an acyl-coenzyme A ligase (ACL). By combining the actions of these catalysts, aliphatic mono- and di-alcohols are converted to the corresponding AMFC-derived amides with yields of up to 65% in aqueous buffer at 60 °C. This process requires only the addition of the enzyme and associated reactants in the same vessel for the second step in an one-pot/two-steps procedure.","PeriodicalId":9813,"journal":{"name":"ChemRxiv","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hybrid synthesis of AMFC-derived amides using supported gold nanoparticles and acyl-coenzyme A ligases\",\"authors\":\"Lucas, Bisel, Aurélie, Fossey-Jouenne, Richard, Martin, Jonathan, Bassut, Antoine, Lancien, Louis, Mouterde, Vivien, Herrscher, Muriel, Billamboz, Carine, Vergne-Vaxelaire, Rénato, Froidevaux, Anne, Zaparucha, Egon, Heuson\",\"doi\":\"10.26434/chemrxiv-2024-2d7wr\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"By integrating different types of catalysts in the same system, hybrid catalysis emerges as an attractive and competitive approach. Within the framework of valorizing sustainably sourced bio-based products, we herein present a synthetic method for producing amides from alcohols and the bio-sourced 5-aminomethyl-2-furancarboxylic acid (AMFC). This approach utilizes supported gold metal nanoparticles as heterogeneous chemocatalysts, in conjunction with an acyl-coenzyme A ligase (ACL). By combining the actions of these catalysts, aliphatic mono- and di-alcohols are converted to the corresponding AMFC-derived amides with yields of up to 65% in aqueous buffer at 60 °C. This process requires only the addition of the enzyme and associated reactants in the same vessel for the second step in an one-pot/two-steps procedure.\",\"PeriodicalId\":9813,\"journal\":{\"name\":\"ChemRxiv\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemRxiv\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26434/chemrxiv-2024-2d7wr\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemRxiv","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26434/chemrxiv-2024-2d7wr","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
通过在同一系统中整合不同类型的催化剂,混合催化技术成为一种极具吸引力和竞争力的方法。在对可持续来源的生物基产品进行价值评估的框架内,我们在此介绍一种从醇和生物来源的 5-aminomethyl-2-furancarboxylic acid (AMFC) 生产酰胺的合成方法。这种方法利用支撑金纳米金属颗粒作为异相化学催化剂,并与酰基辅酶 A 连接酶 (ACL) 结合使用。通过结合这些催化剂的作用,脂肪族一元醇和二元醇可在 60 °C 的水性缓冲液中转化为相应的 AMFC 衍生酰胺,产率高达 65%。该工艺只需在同一容器中加入酶和相关反应物,即可完成一锅/两步法的第二步。
Hybrid synthesis of AMFC-derived amides using supported gold nanoparticles and acyl-coenzyme A ligases
By integrating different types of catalysts in the same system, hybrid catalysis emerges as an attractive and competitive approach. Within the framework of valorizing sustainably sourced bio-based products, we herein present a synthetic method for producing amides from alcohols and the bio-sourced 5-aminomethyl-2-furancarboxylic acid (AMFC). This approach utilizes supported gold metal nanoparticles as heterogeneous chemocatalysts, in conjunction with an acyl-coenzyme A ligase (ACL). By combining the actions of these catalysts, aliphatic mono- and di-alcohols are converted to the corresponding AMFC-derived amides with yields of up to 65% in aqueous buffer at 60 °C. This process requires only the addition of the enzyme and associated reactants in the same vessel for the second step in an one-pot/two-steps procedure.