模式生物枯草杆菌数据库 SubtiWiki 的新框架

Christoph Elfmann, Vincenz Dumann, Tim van den Berg, Jorg Stulke
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摘要

枯草芽孢杆菌是一种革兰氏阳性模式菌,也是研究最多、最易理解的生物之一。对它的研究产生的复杂信息以综合、直观的方式编入数据库 SubtiWiki (https://subtiwiki.uni-goettingen.de/v5)。为了提高 SubtiWiki 的实用性,我们添加了一些新功能,如用于查询保守基因组组织的查看器、显示所有非必要基因突变适配性数据的小工具,以及显示蛋白质结构、结构预测和复杂结构的小工具。此外,我们还将代谢物整合为新的实体。新框架还包括一个文档化的应用程序接口(API),可以通过编程访问数据来完成计算任务。在此,我们将介绍 SubtiWiki 的最新进展以及该生物体的数据现状。
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A new framework for SubtiWiki, the database for the model organism Bacillus subtilis
Bacillus subtilis is a Gram-positive model bacterium and one of the most-studied and best understood organisms. The complex information resulting from its investigation is compiled in the database SubtiWiki (https://subtiwiki.uni-goettingen.de/v5) in an integrated and intuitive manner. To enhance the utility of SubtiWiki, we have added novel features such as a viewer to interrogate conserved genomic organization, a widget that shows mutant fitness data for all non-essential genes, and a widget showing protein structures, structure predictions and complex structures. Moreover, we have integrated metabolites as new entities. The new framework also includes a documented API, enabling programmatic access to data for computational tasks. Here we present the recent developments of SubtiWiki and the current state of the data for this organism.
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